TITLE: Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity

AUTHOR CONTACT:
Emil Unanue
Washington University School of Medicine, St. Louis, MO USA
Phone: 314-362-7440; Fax: 314-362-4096; E-mail: unanue@pathbox.wustl.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=25350

ACCOMPANYING COMMENTARY:

TITLE: A molecule's right to choose: how diabetogenic class II MHC products bind peptides

AUTHOR CONTACT:
Hidde Ploegh
Harvard Medical School, Boston, MA USA
Phone: 617-432-4776; Fax: 617-432-4775; E-mail: ploegh@hms.harvard.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=26018

IMMUNOLOGY
Why pollen makes you go AAHHH-CHOOO!!!

Pollen exposure can cause allergic airway inflammation. The role of antigenic pollen proteins in this allergy is well characterized, but the contribution of other constituents in pollen grains in this process is unknown.

In a new study appearing on August 1 in The Journal of Clinical Investigation, Sanjiv Sur and colleagues from University of Texas Medical Branch show that pollen grains and their extracts contain cell membrane-associated enzymes called NADPH oxidases. These pollen NADPH oxidases increase reactive oxygen species in the lung and other pro-inflammatory factors in the fluid lining the airways.

Removal of NADPH oxidase activity from the pollen inhibited allergic airway inflammation in sensitized mice. Thus, oxidative stress ge
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Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Aug-2005