HOME >> BIOLOGY >> NEWS
JCI Table of contents August 1, 2005

p?id=23076

ACCOMPANYING COMMENTARY:

TITLE: Weaving beta Klotho into bile acid metabolism

AUTHOR CONTACT:
Steven Kliewer
University of Texas Southwestern Medical Center, Dallas, TX USA
Phone: 214-645-6304; Fax: 214-645-6305; E-mail: steven.kliewer@utsouthwestern.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=26046

PHYSIOLOGY
Insulin spares intensive care patients from organ failure and death

It was previously shown, in a large, randomized, controlled trial that controlling blood glucose with insulin reduces the risk of organ failure and death of patients in intensive care. But the underlying mechanisms explaining these clinical benefits remained incompletely understood.

In a new study appearing on August 1 in The Journal of Clinical Investigation, the same group, Greet Van den Berghe and colleagues from Katholieke Universitiet Leuven, show that there is disturbed microcirculation in these patients that is due to endothelial dysfunction which causes inadequate oxygen supply to the cellular systems. The endothelium controls vascular flow and trafficking of important biological molecules. The endothelium of patients with prolonged critical illness is protected by strict blood glucose control with insulin and this may play a major role in the prevention of organ failure and death with this treatment.

This data may open perspectives for novel treatments and for progress in intensive care medicine. In an accompanying commentary, Dandona, et al write, "the results suggest a new paradigm in which glucose and insulin are related not only through their metabolic actions but also through their opposite effects on inflammatory mechanisms."

TITLE: Intensive insulin therapy protects the
'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Aug-2005


Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology news :

1. JCI Table of Contents -- July 2, 2007
2. JCI Table of Contents: July 13, 3006
3. JCI Table of Contents, June 15 2006
4. JCI Table of Contents, April 13, 2006
5. JCI Table of Contents, March 1, 2005
6. JCI table of contents: Aug. 9, 2007
7. JCI table of contents: August 1, 2007
8. JCI table of contents -- July 26, 2007
9. JCI table of contents: July 19, 2007
10. JCI table of contents: July 12, 2007
11. JCI table of contents: June 21, 2007

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017 SomaGenics ... from the NIH to develop RealSeq®-SC (Single Cell), expected ... for profiling small RNAs (including microRNAs) from single cells ... Program highlights the need to accelerate development of approaches ... "New techniques for measuring levels ...
(Date:10/9/2017)... ... , ... The award-winning American Farmer television series will feature 3 Bar Biologics ... at 8:30aET on RFD-TV. , With global population estimates nearing ten billion people ... to feed a growing nation. At the same time, many of our valuable resources ...
(Date:10/7/2017)... ... October 06, 2017 , ... With ... microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical Services. ... range of contract analysis services for advanced applications. Services will leverage techniques ...
Breaking Biology Technology:
Cached News: