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JCI table of contents -- April 19, 2007

with IgG antibodies that recognize ovalbumin. The antibodies were shown to enable immune cells known as dendritic cells to take up dying pancreatic cells expressing ovalbumin and present the ovalbumin to CD8+ T cells (a process known as cross-presentation) in a form that they could "see". Cross-presentation required that the dendritic cells express activating IgG1 receptors. Because ovalbumin-specific antibodies were required for the activation of disease-causing T cells the authors suggest that developing approaches to prevent autoantibodies from enabling dendritic cells to cross-present self antigen to T cells might provide a new approach to treat autoimmune diseases.

TITLE: Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance

AUTHOR CONTACT:

Raphael Clynes
Columbia University, New York, New York, USA.
Phone: (212) 305-5289; Fax: (212) 305-1392; E-mail: rc645@columbia.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=29470


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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Apr-2007


Page: 1 2 3 4 5 6 7

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