HOME >> BIOLOGY >> NEWS
JCI table of contents -- July 26, 2007

EDITOR's PICK

A friendly foe: Bacteria residing in the gut boost immune response to tumors

One potent, immune-based treatment for cancer is total body irradiation (TBI). This approach first depletes the body of the population of immune cells known as lymphocytes and then involves the adoptive transfer of tumor-specific T cells to the patient. Lymphodepletion has previously been shown to improve the ability of tumor-specific T cells to cause tumor regression. In a study appearing online on July 26 in advance of publication in the August print issue of the Journal of Clinical Investigation, Nicholas Restifo and colleagues from the National Cancer Institute show that, in mice, lymphodepletion does not fully account for the tumor regression observed following TBI. They show that a disruption of the population of bacteria that normally reside in the gut without causing disease also plays a role in the effectiveness of this therapeutic approach for cancer.

A specific population of bacteria present in our gut is crucial to our health. However, some treatments for cancer, particularly those that deplete the bodys immune cells, have high potential to disrupt the natural balance between our bodies and these commensal microorganisms, causing disease. Restifo and colleagues subjected mice genetically deficient in lymphocytes to TBI and found that, like TBI-treated mice with intact lymphocytes, TBI was still able to positively augment the function of adoptively transferred tumor-specific CD8+ T cells and cause tumor regression. This surprising result indicated that another mechanism for the efficacy of TBI also exists. They found that in these mutant, irradiated mice the lining of their gut was injured, allowing the passage of commensal bacteria from the gut to the lymph nodes, where the immune response to their presence increased the activation of tumor-specific CD8+ T cells and resulted in tumor regression. This effect was found
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
26-Jul-2007


Page: 1 2 3 4 5 6 7 8

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents: July 19, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... Elgia Therapeutics , ... fibrotic diseases, today announced that Dr. Stacie Canan has joined the company as ... previously served as Executive Director of Global Health at Bristol Myers Squibb (formerly ...
(Date:8/26/2020)... ... August 25, 2020 , ... ... for drugs, biologics, cell and gene therapies, and consumer health products, today announced ... Boston Virtual Conference & Expo, taking place between Aug. 31 – September 4, ...
(Date:8/23/2020)... ... August 21, 2020 , ... The August edition of ... is now available on the company’s global website. Crystallography Times—an electronic newsletter published ... current news and crystallographic research. , The latest issue of Crystallography Times ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/7/2020)... ... July 06, 2020 , ... ... Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General ... World has hosted an elite awards program, highlighting outstanding examples of how technology ...
(Date:7/1/2020)... ... June 29, 2020 , ... The ... purchasing contracts to its membership, recently named BioFit Engineered Products an ... opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts at discounted ...
(Date:6/28/2020)... ... 25, 2020 , ... The Indoor Lab, a leading provider of sensor solutions ... all types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology ... business will provide a health performance index system that scores all aspects of compliance ...
Breaking Biology Technology:
Cached News: