entation of surrounding capillaries, resulting in hemorrhage, tissue necrosis, and neurological dysfunction. The expression of sulfonylurea receptor 1 (SUR1) was increased in the capillaries and neurons surrounding the lesion and also associated with expression of SUR1-regulated, calcium-activated cation channels known as NC[Ca-ATP] channels. The authors went on to show that suppression or blockade of SUR1 activity following spinal cord injury essentially eliminated capillary fragmentation and hemorrhage, reduced spinal cord tissue damage 3-fold, and resulted in marked improvement in mobility in treated versus untreated animals. The results of the study suggest that SUR1-regulated NC[Ca-ATP] channels in the lining of capillaries are critical to the development of progressive hemorrhagic necrosis following spinal cord injury, and as such may constitute a target for therapy in spinal cord injury.

TITLE: Endothelial sulfonylurea receptor1regulated NC[Ca-ATP] channels mediate progressive hemorrhagic necrosis following spinal cord injury

AUTHOR CONTACT:

J. Marc Simard

University of Maryland at Baltimore, Maryland, USA.

Phone : (410) 328-0850; Fax: (410) 328-0756; E-mail: msimard@smail.umaryland.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=32041

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PHYSIOLOGY

The ABCs of getting rid of excess cholesterol

Excess free cholesterol that accumulates along the walls of blood vessels is transported to the liver for excretion via a process known as reverse cholesterol transport. Three proteins, known as ABCA1, SR-BI, and ABCG1, have been shown to promote cholesterol efflux and protect against atherosclerosis in mice, but their roles in mediating reverse cholesterol transport from macrophages remains unclear. In a study appearing
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Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
26-Jul-2007

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