JCI table of contents -- July 26, 2007

online on July 26 in advance of publication in the August print issue of the Journal of Clinical Investigation, Daniel Rader and colleagues from the University of Pennsylvania studied macrophage reverse cholesterol transport in mice and found that ABCA1 and ABCG1, but not SR-BI, promote reverse cholesterol transport in macrophages and that ABCA1 and ABCG1 have additive effects on this process. The data suggest that ABCA1 and ABCG1 cooperatively contribute to macrophage reverse cholesterol transport and that therapeutic intervention to increase macrophage ABCA1 and ABCG1 expression may be an effective strategy to inhibit the development of, or reduce, atherosclerosis.

TITLE: Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo


Daniel J. Rader

University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Phone: (215) 573-4176; Fax: (215) 573-8606; E-mail: rader@mail.med.upenn.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=32057


Activation of liver X receptorbeta lowers cholesterol and reverses atherosclerosis

In animals and humans, the proteins known as liver X receptors (LXRs) sense cholesterol levels. Upon sensing increases in cholesterol, these receptors activate signaling pathways that remove diet-derived cholesterol from the body. Two types of LXRs LXR-alpha and LXR-beta are therefore potential targets for the development of anti-atherosclerosis drugs. However, the effects of synthetic drugs that activate these two receptors have not been well studied. In a study appearing online on July 26 in advance of publication in the August print issue of the Journal of Clinical Investigation, Peter Tontonoz and colleagues from the University of Californ

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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