HOME >> BIOLOGY >> NEWS
JCI table of contents -- March 22, 2007

EDITORS PICK: Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns

Researchers at the University of Edinburgh in the United Kingdom have found that, as for rodents and other nonprimates, prenatal exposure of nonhuman primate African vervet monkeys (Chloroceus aethiops) to glucocorticoids has long-lasting deleterious effects on cardiovascular, metabolic, and neuroendocrine function.

Glucocorticoids are still widely used in obstetric practice. So, Jonathan Seckl and colleagues set out to determine the relevance to human pregnancy of rodent and nonprimate data indicating that prenatal exposure to glucocorticoids (through either the administration of dexamethasone or severe maternal stress) has long-lasting deleterious effects. In the study, which appears online on March 22 in advance of publication in the April print issue of the Journal of Clinical Investigation, they show that although the birth weight of offspring born to nonhuman primate African vervet monkeys treated with dexamethasone from mid-gestation onward did not differ from that of offspring born to untreated animals, the high levels of prenatal dexamethasone impaired postnatal growth, impaired glucose-insulin homeostasis, increased blood pressure 12 months after birth, and increased the production of cortisol in response to mild stress. These data suggest that both repeated glucocorticoid therapy and severe maternal stress late in gestation are likely to have long-term deleterious effects on developing human fetuses.

TITLE: Prenatal dexamethasone exposure induces changes in nonhuman primate offspring cardiometabolic and hypothalamic-pituitary-adrenal axis function

AUTHOR CONTACT:
Jonathan R. Seckl
University of Edinburgh, Edinburgh, United Kingdom.
Phone: 44-131-242-6777; Fax: 44-131-2426779; E-mail: j.seckl@ed.ac.uk.

View the PDF of this article at:

Contact: Karen Honey
215-573-1850
Journal of Clinical Investigation
22-Mar-2007


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... G5, the leader in ... performance up to 25% and reduces cost-per-click by as much as 15%. An ... attribution (MTA) to predict best advertising outcomes and automatically allocate daily ad investments ...
(Date:11/12/2019)... ... November 12, 2019 , ... Atlantic Ultraviolet Corporation ... today that distributors voted their patented automatic and manual wipers the #1 best ... The most frequent maintenance task required of an ultraviolet water purifier is quartz ...
(Date:11/9/2019)... ... ... SiteSeer Technologies, creator of SiteSeer Professional retail site selection software, is pleased ... The boutique real estate developer of single and multi-tenant buildings on sites ranging from ... analysis of markets. , Geoffrey Kerth, manager of GPK Acquisitions, says that his ...
Breaking Biology News(10 mins):
(Date:11/12/2019)... ... November 12, 2019 , ... ... to educate Americans about the deadly healthcare-associated infection C. diff. The campaign, ... of the epidemic, which kills at least 30,000 people in the U.S. each ...
(Date:11/6/2019)... (PRWEB) , ... November 06, 2019 , ... ... leaders through off-the-record collaboration and dialogue, today announces its East/West CEO ... in San Francisco. , Kicking off the week of the ...
(Date:11/5/2019)... ... , ... Ole, a German Shepherd, was demonstrating signs of osteoarthritis in April 2019. He ... level and his willingness to play were normal, it was clear that he was in ... Emergency Animal Hospital and Referral Center in San Diego, California. Dr. Mullen is ...
(Date:11/2/2019)... , ... October 31, 2019 , ... ... by pharma artificial intelligence pioneer tellic. drug360 brings tellic’s expertise in biomedical ... tool allows researchers to quickly uncover relationships between genes, diseases, variants, phenotypes, and ...
Breaking Biology Technology:
Cached News: