JCI table of contents -- March 22, 2007

+81-48-467-6079; Fax: +81-48-467-6079; E-mail: tfuruichi@brain.riken.jp.

View the PDF of this article at: https://www.the-jci.org/article.php?id=29031

ONCOLOGY: Leukemic cells find protection in the bone marrow from anticancer drug

As part of their therapeutic regimen, individuals with acute lymphoblastic leukemia (ALL) are treated with asparaginase a protein that breaks down the amino acid asparagine. ALL cells are sensitive to a lack of asparagine in their environment because they express very low levels of the protein ASNS, which makes asparagine. However, the mechanisms regulating the susceptibility of ALL cells to asparaginase are not completely clear, as ASNS expression levels do not always correlate with clinical effectiveness of the treatment.

In a study that appears online on March 22 in advance of publication in the April print issue of the Journal of Clinical Investigation, Dario Campana and colleagues from St. Jude Childrens Research Hospital, Memphis, show that in vitro, mesenchymal cells (MSCs) from the bone marrow which is where ALL cells grow in patients can provide high levels of asparagine to ALL cells, enabling them to overcome the effects of asparaginse. Protection correlated with the level of ASNS expressed by the MSCs; decreased ASNS expression reduced the ability of MSCs to protect ALL cells from asparaginase, whereas enhanced expression increased their protective capacity. This study indicates that MSCs in the bone marrow can provide protective niches for ALL cells and leads to the suggestion that ASNS in MSCs might be a good target for the treatment of individuals with ALL.

TITLE: Mesenchymal cells regulate the response of acute lymphoblastic cells to asparaginase

Dario Campana
St. Jude Childrens Research Hospital, Memphis, Te

Contact: Karen Honey
Journal of Clinical Investigation

Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:

(Date:6/13/2019)... ... 2019 , ... KICVentures announced today its plans to host an ... Management-Driven ASC Conference in Chicago on Thursday, June 13th at 6:30 pm. The event ... in the 3rd floor Ticino Hospitality room in space #74T. , The event will ...
(Date:6/6/2019)... ... 05, 2019 , ... Pelican BioThermal , the global ... service center in Mexico City, Mexico. Mexico is the second largest pharmaceutical market ... $1.75 billion in pharmaceutical exports since 2015. The Mexico City network station will ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:7/9/2019)... Ky. (PRWEB) , ... July 08, 2019 , ... ... Award winner. The company’s SmartLight Indicator was recognized as the 2019 Innovative Product ... sensors industry forward. The prestigious awards were during Sensors Expo & Conference ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... Calif. (PRWEB) , ... June 11, 2019 , ... ... company of Personalized Stem Cells Inc. (PSC) , has announced that their ... Public Health, Food and Drug Branch for manufacturing. This is an important ...
(Date:5/31/2019)... ... 30, 2019 , ... World Compliance Seminars today announced a ... in Boston, MA. This peer recommended interactive workshop is always selected by professionals ... kick off with a compendial treatment of Data Integrity fundamentals. After laying the ...
Breaking Biology Technology:
Cached News: