JCI table of contents -- March 22, 2007


HEMATOLOGY: Proteins role in blood clotting differs in vitro and in vivo

The formation of a blood clot (also known as a thrombus) is a key step in stopping bleeding after tissue injury. The adhesion of platelets to a blood vessel wall and their subsequent aggregation and activation are essential for thrombus formation. Previous in vitro studies have shown that a protein known as vWF is essential for platelet adhesion, aggregation, and activation in thrombus formation. However, researchers from the Beth Israel Deaconess Medical Center, Boston, have now shown that vWF is not required for in vivo platelet activation in mice in which tissue injury was induced with a laser.

In the study, which appears online on March 22 in advance of publication in the April print issue of the Journal of Clinical Investigation, Bruce Furie and colleagues show that in mice lacking vWF, platelet activation (as measured by calcium mobilization) occurred normally following laser-induced injury, although platelet adhesion and aggregation were impaired. Platelet activation following laser-induced injury was shown to occur via the tissue factormediated pathway and not the collagen-mediated pathway. Therefore, this study indicates that, surprisingly, vWF is not required for in vivo tissue factormediated platelet activation, although other studies have indicated that it might have an in vivo role in collagen-mediated platelet activation.

TITLE: Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model

Bruce Furie
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
Phone: (617) 754-1200; Fax: (617) 754-1234; E-mail: bfurie@caregroup.harvard.edu.

View the PDF of this article a

Contact: Karen Honey
Journal of Clinical Investigation

Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:

(Date:10/19/2019)... ... 2019 , ... The Laser Institute (LIA)'s 38th ... held in Orlando, Florida and featured the conference’s many firsts. A meeting of ... with a deeper industry foci, more expansive technical sessions, and a new Business ...
(Date:10/17/2019)... , ... October 15, 2019 , ... ... Media for the Microbiological Community”. , Microbiology International currently manufactures ready-to-use culture broth ... also offers pre-poured agar plates & liquid supplements. , This major step underpins ...
(Date:10/17/2019)... ... October 16, 2019 , ... The International Society for ... Baseline® Guide: Water and Steam Systems (Third Edition) . This guide provides in-depth ... systems. Industry professionals can better understand Good Manufacturing Practices (GMPs), to comply with ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... ... October 01, 2019 , ... Today Cereset®, the ... the midway point of its randomized research trial for individuals with persisting symptoms ... the efficacy of a non-invasive technology which compares tones delivered to a subject’s ...
(Date:10/3/2019)... ... October 02, 2019 , ... Rapid Novor, Inc., the ... that it has moved into a new, 5000 sqft, purpose-built, state-of-the-art facility. Now ... demonstrates the company's continuous commitment to quality research and service offerings. ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer ... focused on the development of therapies to treat central nervous system (CNS) ...
(Date:9/17/2019)... ... 17, 2019 , ... Catalent, a global leader in clinical ... Asia Pacific (APAC) will present at the upcoming 3rd Annual Accelerating Clinical Trials ... On Thursday, Sept. 26, at 10:10 a.m., Ms. Delaney will present “Singapore: APAC’s ...
Breaking Biology Technology:
Cached News: