HOME >> BIOLOGY >> NEWS
JCI table of contents -- March 22, 2007

t: https://www.the-jci.org/article.php?id=30537


NEPHROLOGY: Disease-causing genetic mutation reveals its molecular secrets

Pseudohypoaldosteronism type 2 (PHA2), also known as Gordon syndrome, is an inherited disease that causes high blood pressure and high levels of potassium in the blood. Recent studies have identified mutations in two genes (WNK1 and WNK4) as causes of PHA2. Although disease-causing WNK4 mutations are known to increase internalization of a cell surface protein known as ROMK1 (which is involved in regulating potassium uptake) by kidney cells, the molecular details behind this increased internalization have not been clearly defined.

In a study that appears online on March 22 in advance of publication in the April print issue of the Journal of Clinical Investigation, Chou-Long Huang and colleagues from the University of Texas Southwestern Medical Center, Dallas, show that in vitro, rat WNK4 interacts with a protein known as ITSN and that this is important for WNK4-mediated internalization of ROMK1 by kidney cells. Furthermore, interactions between WNK4, ITSN, and ROMK1 were enhanced if WNK4 contained the PHA2-causing mutations, leading to increased ROMK1 internalization. This study therefore describes a molecular mechanism for the observation that disease-causing WNK4 mutations increase ROMK1 internalization by kidney cells.

TITLE: Intersectin links WNK kinases to endocytosis of ROMK1

AUTHOR CONTACT:
Chou-Long Huang
University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Phone: (214) 648-8627; Fax: (214) 648-2071; E-mail: chou-long.huang@utsouthwestern.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=30087


'"/>

Contact: Karen Honey
215-573-1850
Journal of Clinical Investigation
22-Mar-2007


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased ... to their online store are now live. Sierra has redesigned entry to the site ... format is more user-friendly and easier to navigate with streamlined menus and simple access ...
(Date:8/21/2019)... ... August 21, 2019 , ... ... cell line for rapid and low-cost biomanufacturing of complex protein therapeutics, today announced ... member of AbSci's Scientific Advisory Board, Dr. Larimore brings more than 30 years ...
(Date:8/19/2019)... ... August 19, 2019 , ... Since the ... of ultra-thin two dimensional slices which are placed on microscope slides, stained and ... tissues and complicated features such as vasculature and thus researchers in the last ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 05, 2019 , ... Advanced Clinical, a clinical ... distinguished leader by PharmaVOICE magazine, earning him a prestigious spot on the 2019 ... special issue. , As the executive vice president of business development and marketing ...
(Date:8/4/2019)... (PRWEB) , ... August 02, 2019 , ... Cirtec Medical ... invasive devices, today announced that it has begun construction on a 30,000 sq. ft. ... 15 miles from San Jose. , The facility, which is expected to be ...
(Date:7/26/2019)... BOSTON (PRWEB) , ... July 25, 2019 , ... ... senior-level biopharma leaders through off-the-record collaboration and dialogue, today announces its Boston ... Boston Waterfront Hotel. As part of Biotech Week Boston , the event ...
(Date:7/19/2019)... ... July 18, 2019 , ... Global precision motion ... their current piezo motion facilities in Lederhose, Germany, increasing their current footprint by ... ceramic assembly production in addition to general office space, a significant increase to ...
Breaking Biology Technology:
Cached News: