JCI table of contents -- March 8, 2006


PULMONARY: Mesenchymal stem cells are long-term tissue residents

The process of repairing a damaged tissue requires the generation of a new set of the cells that form that tissue. Most tissues contain connective tissue cells and these can be derived from mesenchymal stem cells (MSCs). However, it has not been clearly determined whether MSCs are recruited to a damaged tissue from the bone marrow or whether each tissue has its own population of resident MSCs.

In a study that appears online on March 8 in advance of publication in the April print issue of the Journal of Clinical Investigation, Vibha Lama and colleagues from the University of Michigan, Ann Arbor, show that in transplanted human lungs there is a tissue-resident population of MSCs. Cells that expressed the cell surface molecules known to characterize MSCs and that were able to generate various connective tissue cells were isolated from transplanted human lungs. In cases where the transplant donor and recipient were not of the same sex it was determined that the MSCs were nearly all (97.2% 2.1%) of donor origin, indicating that they had persisted in the tissue since the time of transplantation. This study indicates that the lung contains a population of long-lived tissue-resident MSCs, raising the possibility that other organs also have a tissue-resident MSC population.

TITLE: Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts

Vibha N. Lama
University of Michigan Health System, Ann Arbor, Michigan, USA.
Phone: (734) 936-5201; Fax: (734) 936-8266; E-mail: vlama@umich.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=29713

PULMONARY: SPDEF makes the lungs

Contact: Karen Honey
Journal of Clinical Investigation

Page: 1 2 3 4 5

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