HOME >> BIOLOGY >> NEWS
JCI table of contents, December 15 2004

Oxidants link obesity to diabetes

Individuals with the metabolic syndrome are at risk of coronary heart disease, stroke, vascular disease, and type 2 diabetes. Although risk factors for this syndrome are known to include obesity, physical inactivity, and genetic factors, the mechanistic role of obesity is not completely understood. In the December 15 issue of the Journal of Clinical Investigation, Iichiro Shimomura and researchers from Osaka University, Japan, show that fat cells of obese mice produce increased levels of toxic oxygen molecules known as reactive oxygen species (ROS) as well as the enzyme NADPH oxidase. Furthermore, these cells express decreased levels of antioxidative enzymes that are responsible for destroying these toxic forms of oxygen. The effect of this oxidative stress causes changes in the production of fat-derived hormones known as adipocytokines.

The authors found that treatment of these mice with apocynin an antioxidant that inhibits NADPH oxidase reduced ROS production in fat cells, restored adipocytokine production to normal, improved diabetes, and reduced the levels of fat present in the blood and liver.

The results suggest that accumulated fatty tissue is a major source of ROS in obesity and acts as an early trigger of the metabolic syndrome. While it is too early to suggest that taking antioxidants may counter the development of obesity-associated metabolic syndrome, the steps leading to excess ROS generation may represent a potentially useful therapeutic target.

TITLE: Increased oxidative stress in obesity and its impact on metabolic syndrome

AUTHOR CONTACT:
Iichiro Shimomura
Department of Internal Medicine and Molecular Science, Osaka University, Osaka, Japan.
Phone: 81-6-6879-3730; Fax: 81-6-6879-3739; E-mail: ichi@imed2.med.osaka-u.ac.jp.

A PDF of this article is available at:

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Dec-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents December

(Date:4/9/2015)... Synaptics Inc. (NASDAQ: SYNA ), a leading ... will report financial results for the third quarter of ... close of market. The company will host a corresponding ... PT (5:00 p.m. ET), during which management may discuss ... live call, analysts and investors should dial 888-438-5524 (conference ...
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
(Date:3/31/2015)...   Guidepoint , a leading global research services ... Management TRACKER, part of the Guidepoint TRACKER ... medical device and therapeutics markets. The Post-Surgical Pain Management ... market share, and adoption rates across three major modalities ... The Post-Surgical Pain Management TRACKER will provide ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
(Date:4/23/2015)... Florida (PRWEB) April 23, 2015 ... it intends to conduct a groundbreaking pilot study ... to be reversed in as little as three ... science of metabolic and nutritional medicine—will aggressively target ... cripple and destroy our aging brain. These include ...
(Date:4/23/2015)... BioTE Medical President and Founder Gary ... Happier - Avoiding Over-Medication through Natural Hormone Balance" (ISBN: ... Conference at JW Marriott / Ritz Carlton Grande Lakes ... Live Happier, is a welcomed response to many men ... a higher quality of life thanks to bio-identical hormone ...
(Date:4/23/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... 2015 results before the Nasdaq market opens on Thursday, ... call and webcast to discuss its financial results and ... at 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... by dialing 866-952-1906 (US) or 785-424-1825 (International) using the ...
(Date:4/23/2015)... Follow us on LinkedIn ... of genetic tests that determine individual susceptibility to ... Huntington's disease, and Alzheimer's disease. Predictive diagnostics are ... interaction in diseased tissue/cells to understand and determine ... response to treatment, such as in the numerous ...
Breaking Biology Technology:New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3
Cached News: