JCI table of contents, December 15 2004

Joan Massagu
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Phone: 212-639-8975; Fax: 212-717-3298; E-mail: j-massague@ski.mskcc.org.

A PDF of this article is available at: http://www.jci.org/cgi/content/full/114/12/1691.

Return of the Staphylococcus aureus "superbug"

Staphylococcus aureus causes a wide variety of diseases including boils and furuncles and more serious diseases such as septicemia and pneumonia, and a debate has long raged about the existence of S. aureus "superbugs" more dangerous strains that may be associated with particularly invasive disease.

In the December 15 issue of the Journal of Clinical Investigation, Damian Melles and colleagues from University Medical Center Rotterdam examined 829 S. aureus strains from healthy donors from the city of Rotterdam. The genetic relatedness of the strains was compared and revealed the existence of 3 major and 2 minor genetic clusters. These clusters corresponded to the predominant genetic groups identified in a similar analysis recently performed in the United Kingdom, indicating that the same clonal lineages of the organism appear to be dominant in 2 distinct geographic locations.

Surprisingly, while the 2003 UK-based study found no evidence of hypervirulent clones or "superbugs" assocated with particularly invasive forms of disease, Melles et al. examined isolates from individuals with bacteriemia, deep-seated abscesses, or impetigo and found clear evidence that some strains of S. aureus are more virulent that others in that they appear more frequently in people with serious S. aureusrelated disease that healthy individuals that simply carry the organism without falling prey to infection.

In an accompanying commentary, Ti

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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