nderstood. In the December 15 issue of the Journal of Clinical Investigation, Xiao-Song He and colleagues from the VA Medical Center in Palo Alto demonstrate that upon exposure of adult cells to fluA, NK cells produce IFN-gamma, which stimulates the immune system to destroy foreign material. The authors further demonstrate that T cells previously exposed to fluA (known as virus-specific memory T cells), express IL-2, which is required in order to initiate subsequent IFN-gamma secretion by NK cells. Taken together, these data and results of previous work support the notion that a number of reciprocal interactions exist between components of the innate and adaptive immune response, which collectively facilitate a successful immune response to clear an infection.

TITLE: T celldependent production of IFN-gamma by NK cells in response to influenza A virus

AUTHOR CONTACT:
Xiao-Song He
Veteran's Administration Medical Center, Palo Alto, California, USA.
Phone: 650-493-5000, ext. 66135; Fax: 650-852-3259; E-mail: xiaosong@stanford.edu.

A PDF of this article is available at: : http://www.jci.org/cgi/content/full/114/12/1812.

---

Eph affects T cell function

The erythropoietin-producing hepatocyte (Eph) kinases are the largest family of receptor tyrosine kinases in the immune system. The Eph kinases and their ligands are known to direct neural outgrowth, the growth of new blood vessels, and epithelial cell migration in the intestine. In the December 15 issue of the Journal of Clinical Investigation, Jiangping Wu and colleagues from Notre Dame Hospital, Montreal, now delve further into the role of Eph kinases in the immune system by showing that EphB6 modulates immune function. The authors demonstrated that mice genetically deficient for EphB6 have compromised T cell responses. On
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Dec-2004

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