HOME >> BIOLOGY >> NEWS
JCI table of contents, December 15 2004

niversity of Oxford, Oxford, United Kingdom.
Phone: 44-1865-222412; Fax: 44-1865-222502; E-mail: vincenzo.cerundolo@imm.ox.ac.uk.

A PDF of this article is available at: http://www.jci.org/cgi/content/full/114/12/1800.


Understanding acid sensing in the kidney

The normal daily diet generates volatile acid (carbon dioxide) and nonvolatile acid (hydrogen ions) from carbohydrate and protein metabolism, respectively, and the kidney is responsible for maintaining an acid-base balance by excreting these acids. In this issue of the Journal of Clinical Investigation, Patricia Preisig and colleagues from the University of Texas Southwestern Medical Center have identified the kidney's elusive acid sensor. The authors examined opossum kidney cells cultured under acidic conditions and found that a 24-hour exposure to acid activates the enzyme Pyk2, which then binds to the proto-oncogene c-Src, causing c-Src activation and subsequent activation of signaling pathways that increase production of NHE3, the molecule at the surface of renal proximal tubule cells in the kidney that release hydrogen ions from the cell.

In an accompanying commentary, Steven Gluck from the University of California San Francisco discusses the broader role of Pyk2 in acid-base balance in bone and other tissues beyond the kidney.

TITLE: Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3

AUTHOR CONTACT:
Patricia Preisig
University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Phone: 214-648-8628; Fax: 214-648-2071; E-mail: Patricia.Preisig@UTSouthwestern.edu.

A PDF of this article will be available at:

A PDF of this article is available at:

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Dec-2004


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... SPRING, Md. and RESEARCH TRIANGLE ... United Therapeutics Corporation (NASDAQ: UTHR ) today ... of up to $250 million of the company,s common ... remain open through December 31, 2017. Purchases may be ... in privately negotiated transactions from time to time as ...
(Date:4/27/2017)... ... April 27, 2017 , ... Arrowhead Publishers is pleased to ... coming to San Diego, CA on September 27-28, 2017. Leaders from the pharmaceutical, ... advances in the treatment of various types of pain. There are also extended ...
(Date:4/27/2017)... ... April 27, 2017 , ... The ... Communication Award goes to Jayson Lusk, a consummate communicator who promotes agricultural science ... advocate for science, as he explains how innovation and growth in agriculture are ...
(Date:4/26/2017)... ... April 26, 2017 , ... Led by ... I clinical trials comes to Tampa, San Francisco and Boston in 2017. ... FDA regulated organizations such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular Therapeutix ...
Breaking Biology Technology:
Cached News: