HOME >> BIOLOGY >> NEWS
JCI table of contents, February 23, 2006

EDITOR'S PICK

Drawing a crowd: recruiting cells from the bone marrow to blood vessels in tumor growth

Cells within the bone marrow (progenitor cells) that express a protein called CD34 have been shown to leave the marrow and travel to sites of tissue injury to mediate repair. Once the cells arrive at the site of injury it has been demonstrated that they can turn into a variety of different cell types, including blood vessel cells, muscle cells, nerve cells, and blood cells, which enhances wound healing. However, the mechanisms responsible for recruiting these CD34-positive progenitor cells from the bone marrow and to the site of tissue damage are unclear. Now, in a study appearing online on February 23 in advance of print publication in the March issue of the Journal of Clinical Investigation, Judy Varner and colleagues from the University of California, San Diego show that a protein called alpha4-beta1 integrin (or VLA-4) promotes the homing of these progenitor cells to VLA-4binding molecules called VCAM and fibronectin found on both actively healing and tumor-associated blood vessels. The researchers found that progenitor cells were drawn to sites of active blood vessel formation in tumors, but not to normal tissues, due to the presence of VLA-4 in the tumor vessels. In addition, the authors found that blocking VLA-4 with an antibody prevented the progenitor cells from sticking to blood vessels, from migrating to newly formed vessels, and from changing into different cell types. Together these studies support a potent role of VLA-4 in the regulation of bone marrowderived progenitor cells in wound repair and migration. The authors suggest that inhibiting this homing process could be useful in suppressing new blood vessel formation in tumors.

TITLE: A homing mechanism for bone marrowderived progenitor cell recruitment to the neovasculature

AUTHOR CONTACT:
Judy Varner
University of California, San Diego, La Jolla, Ca
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
23-Feb-2006


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   Valencell ... sensor technology, and STMicroelectronics (NYSE: STM), a ... of electronics applications, announced today the launch of ... for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, SensorTile ...
(Date:12/16/2016)... Research and Markets has announced the addition of the ... report to their offering. ... The biometric vehicle access system market, in terms ... from 2016 to 2021. The market is estimated to be USD ... by 2021. The growth of the biometric vehicle access system market ...
(Date:12/15/2016)... --  WaferGen Bio-systems, Inc. (NASDAQ: WGBS ... that on December 13, 2016, it received a letter ... Market LLC which acknowledged that, as of December 12, ... had been at $1.00 or greater for ten consecutive ... Rule 5550(a)(2) of the Nasdaq Stock Market. ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... January 18, 2017 , ... The American Medical Informatics Association ... Data Sharing Policy. Specifically, the nation’s leading informatics experts, said data sharing plans ... policy. AMIA recommended that NIH earmark funding for researchers to produce and execute ...
(Date:1/19/2017)... 18, 2017 The global biotechnology services ... billion by 2025, according to a new report ... been adaptive of the function of outsourcing certain ... Among the services outsourced, clinical trial management and ... & Johnson was the first pharmaceutical company to ...
(Date:1/18/2017)... ... January 18, 2017 , ... ... interconnect using USB or PCI Express, announced the ZEM5310 USB 3.0 FPGA Module, ... into a compact business-card sized form factor suitable for prototyping, testing, and production-ready ...
(Date:1/18/2017)... , Jan. 18, 2017   Parent Project ... fight to end Duchenne muscular dystrophy (Duchenne) , ... the New Jersey Institute of Technology (NJIT) and Talem ... exploration of robotic technology to assist people living ... incorporate NJIT,s technology – an embedded computer, software, a ...
Breaking Biology Technology:
Cached News: