atitis). Similarly, mice injected directly with DNA molecules that produced LIGHT protein had much lower survival rates and higher liver inflammation than mice injected with control DNA or mutated LIGHT DNA molecules. Using antibodies that block the specific interaction between LIGHT and LTbetaR, the authors discovered that LIGHT required LTbetaR interaction to mediate liver inflammation. These studies demonstrate a direct role for the proinflammatory LIGHT protein in liver inflammation (hepatitis), liver damage, and associated mortality.

TITLE: Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis

AUTHOR CONTACT:
Koji Tamada
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Phone: (410) 502-0958; Fax: (410) 502-0961; E-mail: ktamada1@jhmi.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=27083

NEPHROLOGY

Defying gravity: the ups and downs of blood pressure control in the kidney

In a study appearing online on March 23 in advance of print publication in the April issue of the Journal of Clinical Investigation, Scott Thomson and colleagues at the University of California, San Diego, California, report the surprising role for the peptide hormone angiotensin II (Ang II) in regulating blood pressure via kidney fluid reabsorption during highdietary salt intake. The authors placed rats on high-salt diets and monitored the amount of fluid reabsorbed in the proximal tubule portion of the kidney (an important region for controlling blood volume and hence pressure). In addition, the researchers gave the rats a drug called losartan, which blocks the action of Ang II. Rats on a standard diet taking losartan demonstrated a 25% reduction in proximal fluid reabsorption, suggesting that Ang II signaling can mediat
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
23-Mar-2006

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