HOME >> BIOLOGY >> NEWS
JCI table of contents, March 9, 2006

Medicine, New York, New York, USA
Phone: (718) 430-4118; Fax: (718) 430-8557; E-mail: rossetti@aecom.yu.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=26640

CARDIOVASCULAR BIOLOGY

How sweet it is: scientists find cellular link between insulin resistance and heart disease

Insulin resistance (IR) is a metabolic disorder in which the body does not respond to the insulin produced by the pancreas, typically resulting in elevated blood sugar levels and diabetes. Importantly, individuals with diabetes also have a significantly higher risk of developing cardiovascular disease (CVD), even after accounting for risk factors such as elevated cholesterol levels and high blood pressure. Now, in a study appearing online on March 9 in advance of print publication in the April issue of the Journal of Clinical Investigation, Michael Brownlee and colleagues at Albert Einstein College of Medicine in New York show a link between the metabolism of lipids called free fatty acids (FFAs) and a tissue damaging oxidant called "superoxide." The researchers measured the effects of FFA metabolism in cells from the aortas of cows, when the cells were treated with a high sugar solution to mimic the events that occur in the blood vessels during insulin resistance and diabetes. The authors found that the cells metabolized FFAs, which led to increased production of superoxide and the activation of a variety of inflammatory signals previously implicated in highblood-sugarinduced vascular damage. In addition, the authors also found that two important antiatherogenic enzymes, prostacyclin synthase and eNOS, were inactivated, suggesting that insulin resistance and high blood sugar can directly damage the cells of blood vessels, contributing to heart disease. The researchers also examined mouse and rat animal models of insulin resistance
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
9-Mar-2006


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... ... September 17, 2019 , ... Dual-board certified periodontist ... the Australia Society of Implant Dentistry (ASID) Accreditation Courses. His lecture, “Understanding the ... Surgical Aspects of Modern Implant Dentistry course. Dr. Kim’s expertise comes from years ...
(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... CARLSBAD, Calif. (PRWEB) , ... ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed ... combines CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 09, 2019 , ... Tunnell ... government agencies, announced that its president and CEO Maryann Gallivan has been accepted ... , The Forbes Council accepted Gallivan based on the role she and ...
(Date:9/11/2019)... N.J. (PRWEB) , ... September 10, 2019 , ... ... development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, ... Forum, to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, Germany, ...
(Date:9/8/2019)... ... 2019 , ... Spartan Bioscience, the leader in on-demand DNA ... has been named Chief Financial Officer. , Spartan has also named former ... Additionally, Spartan has hired Steve Edgett as Executive Vice President to lead international ...
(Date:8/29/2019)... (PRWEB) , ... August 29, 2019 , ... ... chronic disease affecting grapevines, a feat they hope will ultimately help protect the ... Researchers including several Rochester Institute of Technology faculty and alumni sequenced the microbiome ...
Breaking Biology Technology:
Cached News: