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JCI table of contents, March 9, 2006

, and found that inactivation of prostacyclin synthase and eNOS was prevented by reduction of superoxide levels. The study results suggest that these experiments have identified a novel mechanism that contributes to the accelerated cardiovascular disease risk occurring in people with insulin resistance.

TITLE: Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation

AUTHOR CONTACT: Michael Brownlee
Albert Einstein College of Medicine, Bronx, New York, USA
Phone: (718) 430-3636; Fax: (718) 430-8570; E-mail: brownlee@aecom.yu.edu
View the PDF of this article at: https://www.the-jci.org/article.php?id=23354

ENDOCRINOLOGY

Creating vitamin D-related compounds with fewer side effects for the treatment of osteoporosis and skin disorders

Vitamin D and drugs with structures similar to vitamin D, are called vitamin D receptor (VDR) ligands because they exert their actions in the body by binding to a special cell protein called the vitamin D receptor. Importantly, VDR ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and show immense therapeutic potential for autoimmune diseases and cancers of skin, prostate, colon, and breast as well as leukemia. However, the major side effect of VDR ligands is hypercalcemia, which develops due to adverse effects in the intestine. In a study appearing online on March 9 in advance of print publication in the April issue of the Journal of Clinical Investigation, researchers Sunil Nagpal and colleagues at Eli Lilly and Company describe new drugs called "tissue-selective VDR modulators" or VDRMs), which have high activity in skin and bone, with poor activity in the intestine, therefore reducing the negative side effects of these compounds. The researcher designed two compounds calle
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
9-Mar-2006


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