JCI table of contents, March 9, 2006

d LY2108491 and LY2109866, and found that mice treated with these compounds developed increased thickness of the epidermal layer of their skin, a model which suggests that the compounds will inhibit psoriasis-related symptoms in humans. Using isolated human cells in laboratory dishes, the authors also showed that these compounds have potent action in other target cells such as keratinocytes of the skin, osteoblasts of bone, and blood cells. Further work on these and related compounds may lead to the development of potent treatments for cancers, psoriasis, and osteoporosis that have fewer unwanted side effects.

TITLE: Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators

Eli Lilly and Company, Indianapolis, Indiana, USA
Phone: (484) 865-5627; Fax: (484) 865-9389; E-mail: nagpals@wyeth.com
View the PDF of this article at: https://www.the-jci.org/article.php?id=25901


Human gene mutation causes kidney stones and kidney failure

Mutations in a human gene known as Claudin16 are responsible for certain causes of kidney failure and kidney stones, and increased urine calcium and magnesium levels. However, the precise effects that these different mutations have on claudin16 protein structure and biological action are unclear. Now, in a study appearing online on March 9 in advance of print publication in the April issue of the Journal of Clinical Investigation, Walter Hunziker and colleagues from the Institute of Molecular and Cell Biology in Singapore have identified that the majority of mutations in claudin16, which is normally located on the surface of kidney cells, cause the protein to get stuck inside the cells or get degraded by the cell's own protein-destroying machinery. The researchers created 2

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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