HOME >> BIOLOGY >> NEWS
JCI table of contents, March 9, 2006

1 synthetic DNA molecules called "plasmids" which each contained a single mutant form of the claudin16 gene sequence, and put these plasmids into kidney cells in the laboratory. The cells were able to produce the mutant claudin16 protein. The authors made an antibody that recognized claudin16 protein and used it to determine where in the cells the various mutants were localized. Incubating the cells with this antibody revealed that most of the mutants, in contrast to the normal version of claudin16, were either degraded by the cell or they became trapped in various places inside the cell and thus could not function properly. In addition, when the researchers examined the movement of calcium and magnesium in and out of the cells, they found that cells that expressed the mutant claudin16 forms of the protein had defects in trafficking calcium and magnesium. The authors report that this study is important for the potential future therapeutic interventions that claudin16 corrective therapy may provide for patients with excess calcium loss due to these genetic mutations.

TITLE: Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16

AUTHOR CONTACT: Walter Hunziker
Institute of Molecular and Cell Biology, Singapore
Phone: 65-6586-9599; Fax: 65-6779-1117; E-mail: hunziker@imcb.a-star.edu.sg
View the PDF of this article at: https://www.the-jci.org/article.php?id=26323

IMMUNOLOGY

New mechanism for allergic asthma identified

In a study appearing online on March 9 in advance of print publication in the April issue of the Journal of Clinical Investigation, Gesine Hansen and colleagues at Medizinische Hochschule Hannover in Germany have identified a potentially new target for treating asthma. The researchers examined a mouse model of asthma
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
9-Mar-2006


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years old when her owners ... dysplasia, which caused painful osteoarthritis in the joints. She was referred to a ... , The surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty Hospital ...
(Date:6/1/2019)... ... May 31, 2019 , ... The University ... recently invested in BioFactura’s $6M Series B Financing Round. , “With the ... investors who bring significant financial and business resources to bear as we advance ...
(Date:5/31/2019)... (PRWEB) , ... May 30, 2019 , ... Enso Discoveries ... and especially during Military Appreciation Month, as a way to express his gratitude and ... and the company he founded — Enso Discoveries — presented a check ...
Breaking Biology News(10 mins):
(Date:5/22/2019)... ... 2019 , ... Artemis (formerly Agrilyst), the leading enterprise Cultivation Management ... co-led by Astanor Ventures and Talis Capital with participation from ... Fund . The company has raised $11.75m to date and will use the new ...
(Date:5/14/2019)... , ... May 13, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging ... website. The redesigned website aims to improve LDA’s ability to communicate directly with ...
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, ... (DF). Urandir detailed the results of some research carried out by the association, ...
(Date:5/2/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology ...
Breaking Biology Technology:
Cached News: