JCI table of contents, March 9, 2006

, which develops human-like asthma symptoms including airway hyperresponsiveness (AHR), mucus production, production of proinflammatory proteins called cytokines, and increased numbers of immune cells called eosinophils and Th2 cells in the lung. The researchers injected these asthmatic mice with an antibody that stimulates the activity of an immune protein called CD137. A single injection of this "agonistic" anti-CD137 antibody was able to inhibit AHR, eosinophilic airway inflammation, and Th2 cytokine production for the complete observation period of almost 7 weeks. The lasting effects of this treatment suggest that this type of antibody therapy may be used in the future to treat the recurring symptoms of allergy in humans. Specifically, the authors suggest that strategies aimed at stimulation of CD137, which has previously been shown to induce tumor rejection, may represent a clinical target for allergic inflammatory responses and other disorders characterized by inappropriate T cell activation.

TITLE: CD137-mediated immunotherapy for allergic asthma

Medizinische Hochschule
Hannover, Hannover, Germany
Phone: 0049-511-532-9138; Fax: 0049-511-532-9125; E-mail: hansen.gesine@mh-hannover.de
View the PDF of this article at: https://www.the-jci.org/article.php?id=23792


Contact: Brooke Grindlinger
Journal of Clinical Investigation

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