HOME >> BIOLOGY >> NEWS
JCI table of contents, May 18, 2006

EDITOR'S PICK

A non-invasive method for measuring beta cell mass during diabetes

Diabetes results from a reduction in the number of islet beta cells in the pancreas, which leads to insufficient insulin secretion and high blood glucose levels (hyperglycemia). Currently, insulin secretion is used as a surrogate measure of beta cell mass. However serum insulin concentrations provide an imprecise measure of beta cell mass, and no reliable non-invasive measure of beta cell mass has been available, until now. In a study appearing online on May 18 in advance of print publication in the June issue of the Journal of Clinical Investigation, Paul Harris and colleagues from Columbia University in New York report that positron emission tomography (PET)-based quantitation of pancreatic radiolabeled VMAT2 receptors in diabetic rats is a reliable and non-invasive way to measure beta cell mass.

The authors exploited the finding that type 2 vesicular monoamine transporters (VMAT2) are expressed in human islet beta cells within the pancreas, as well as in tissues of the central nervous system. As the radioligand [11C]Dihydrotetrabenazine (DTBZ) binds specifically to VMAT2 and is currently used in clinical imaging of the brain, the authors were able to use DTBZ to estimate beta cell mass in rats with type 1 diabetes. In longitudinal PET studies, the authors saw a significant decline in pancreatic uptake of DTBZ that preceded the loss of glycemic control in the diabetic rat. These studies suggest that PET-based quantitation of VMAT2 receptors could provide a non-invasive measurement of beta cell mass that could be used to study the pathogenesis of diabetes and to monitor therapeutic interventions.

TITLE: Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model

AUTHOR CONTACT:
Craig LeMoult
Press Office, Columbia University Medical Center, New York, New York, USA.
Phone: (212)
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
18-May-2006


Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2016)... MOUNTAIN VIEW, Calif. , Dec. 20, 2016  As ... all levels, 23andMe, the leading personal genetics company, recently released ... Only Me . The book focuses on the topics ... the Next Generation Science Standards (NGSS) taught in elementary school ... the second in a series by illustrator Ariana Killoran ...
(Date:12/19/2016)... , España y TORONTO , 19 de diciembre ... Northern Biologics Inc. que permitirá el desarrollo acelerado de MSC-1, un ... en varios tipos de tumor en 2017, con múltiples sitios previstos ... ... clase con objetivo en el factor inhibidor de leucemia (LIF), una ...
(Date:12/15/2016)... VANCOUVER, Canada and BADEN-BADEN, Germany ... Solutions, a leading global financial services provider, today announced an ... in passive behavioural biometrics, to join forces. The partnership will ... fraud mitigation strategies in compliance with local data protection regulation. ... In ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... 2017  Market Research Future has a half cooked research report ... is growing rapidly and expected to reach USD 450 Million by ... ... Market has been assessed as a swiftly growing market and expected ... the coming future. There has been a tremendous growth in the ...
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... ... delivery of product vigilance software to leading biopharmaceutical and medical device manufacturers and ... is a fully 21 CFR Part 11-compliant email client designed to provide product ...
(Date:1/19/2017)... ... January 18, 2017 , ... LabRoots , ... from around the world, was today awarded the "Best Science & Technology Social ... on merit and decided upon by a dedicated team of researchers and analysts. ...
(Date:1/19/2017)... N.Y. , Jan. 18, 2017 Acupath ... services, announces the formation of an Executive Committee that ... and beyond. John Cucci , a ... promoted from Director of Business Development to Chief ... 2015, Mr. Cucci served in senior sales leadership roles ...
Breaking Biology Technology:
Cached News: