HOME >> BIOLOGY >> NEWS
JCI table of contents, May 18, 2006

EDITOR'S PICK

A non-invasive method for measuring beta cell mass during diabetes

Diabetes results from a reduction in the number of islet beta cells in the pancreas, which leads to insufficient insulin secretion and high blood glucose levels (hyperglycemia). Currently, insulin secretion is used as a surrogate measure of beta cell mass. However serum insulin concentrations provide an imprecise measure of beta cell mass, and no reliable non-invasive measure of beta cell mass has been available, until now. In a study appearing online on May 18 in advance of print publication in the June issue of the Journal of Clinical Investigation, Paul Harris and colleagues from Columbia University in New York report that positron emission tomography (PET)-based quantitation of pancreatic radiolabeled VMAT2 receptors in diabetic rats is a reliable and non-invasive way to measure beta cell mass.

The authors exploited the finding that type 2 vesicular monoamine transporters (VMAT2) are expressed in human islet beta cells within the pancreas, as well as in tissues of the central nervous system. As the radioligand [11C]Dihydrotetrabenazine (DTBZ) binds specifically to VMAT2 and is currently used in clinical imaging of the brain, the authors were able to use DTBZ to estimate beta cell mass in rats with type 1 diabetes. In longitudinal PET studies, the authors saw a significant decline in pancreatic uptake of DTBZ that preceded the loss of glycemic control in the diabetic rat. These studies suggest that PET-based quantitation of VMAT2 receptors could provide a non-invasive measurement of beta cell mass that could be used to study the pathogenesis of diabetes and to monitor therapeutic interventions.

TITLE: Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model

AUTHOR CONTACT:
Craig LeMoult
Press Office, Columbia University Medical Center, New York, New York, USA.
Phone: (212)
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
18-May-2006


Page: 1 2 3 4 5 6 7 8 9 10 11

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- The Prostate Cancer Foundation (PCF) is pleased to announce 24 new ... prostate cancer. Members of the Class of 2016 were selected from a pool ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , a ... $1 million in debt financing from Silicon Valley Bank ... automation and to advance its drug development efforts, as ... facility. "SVB has been an incredible strategic ... services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... STACS DNA ... Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a ... STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
Breaking Biology Technology:
Cached News: