JCI table of contents, November 15 2004

TITLE: Loss of alpha-hemoglobinstabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia

AUTHOR CONTACT: Mitchell J. Weiss
The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: 215-590-0565; Fax: 215-590-4834; E-mail: weissmi@email.chop.edu.

View the PDF of this article at: https://www.the-jci.org/press/21982.pdf


Desmoglein 4 shown to have no role in disrupted adhesion of skin cells in the skin-blistering disease pemphigus

Data disproves early theory

Pemphigus is a group of rare blistering diseases of the skin and/or mucous membranes that occur when the immune system produces antibodies that mistakenly perceive cells of the skin or mucous membranes as foreign, and attacks them. Desmogleins, a family of proteins that function to attach one cell to its neighbor, when attacked by autoantobodies, become separated from each other causing burn-like lesions or blisters that do not heal. To date, four types of desmogleins have been described Dsg14 and in the November 15 issue of the Journal of Clinical Investigation, Masayuki Amagai and colleagues from Keio University in Tokyo investigated the involvement of Dsg4, expressed in the superficial layer of the skin, in pemphigus and staphylococcal scalded skin syndrome (SSSS).

Surprisingly, and in contrast to earlier work suggesting a role for Dsg4 in pemphigus, the authors found that although autoantobodies that recognize Dsg4 are present in the sera of pemphigus patients, these antibodies cross-react with Dsg1 and removal of anti-Dsg4 antibodies did not affect the pathogenicity of the remaining Dsg1 autoantobodies. Is SSSS, Dsg1 is targeted for cle

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:

(Date:8/26/2020)... ... August 24, 2020 , ... Elgia Therapeutics ... and fibrotic diseases, today announced that Dr. Stacie Canan has joined the company ... Canan previously served as Executive Director of Global Health at Bristol Myers Squibb ...
(Date:8/26/2020)... ... , ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, ... list is the most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions ... reported three-year revenue growth of 71 percent. , The Inc. 5000 list represents ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... , ... August 03, 2020 , ... Introducing Ardent Animal ... transformative growth, , Known as MediVet Biologics since its formation ... The new Ardent Animal Health will build on its base of innovative ...
(Date:7/31/2020)... Mass. and SOMERSET, N.J (PRWEB) , ... July ... ... leading genome editing company, and Catalent, the leading global provider of advanced delivery ... consumer health products, today announced that they have entered into a strategic partnership ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... , ... July 09, 2020 ... ... company, announced today that Massachusetts Institute of Technology (MIT) has expanded the ... license allows PathSensors to move into the point-of-care diagnostic market, focusing initially ...
Breaking Biology Technology:
Cached News: