JCI table of contents, November 15 2004

avage by exfoliative toxins (ETs) of Staphylococcus aureus, however Amagai et al. found that ETs did not cleave Dsg4, suggesting that Dsg4 could not compensate for the loss of Dsg1 after ET cleavage. In sum, the authors concluded that Dsg4 must play a role other that adhesion in the development of pemphigus and SSSS.

TITLE: Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.

AUTHOR CONTACT: Masayuki Amagai
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Phone: 81-3-5363-3425; Fax: 81-3-3351-6880; E-mail: amagai@sc.itc.keio.ac.jp.

View the PDF of this article at: https://www.the-jci.org/press/20480.pdf


Par1 for the course in inflammatory bowel disease

An estimated more than 1 million Americans suffer from ulcerative colitis or Crohn's disease, the two most common forms of inflammatory bowel disease (IBD), which cause painful and debilitating chronic inflammation of the digestive tract. Thought to result from a variety of genetic and environmental factors, scientists have yet to gain a complete picture of the mechanisms of this disease. In the November 15 issue of the Journal of Clinical Investigation, Nathalie Vergnolle and colleagues found that IBD patients have increased levels of protein-activated receptor1 (PAR1) in the colon. In mice, activation of PAR1 resulted in increased severity and duration of inflammation requiring T and B cells. Conversely, drugs that inhibit PAR1 activity were shown to greatly reduce inflammation. The results point to the importance of PAR1 activity in IBD and indicate that PAR1 inhibition may be useful in treating IBD and other chronic intestinal inflammatory conditions.

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:

(Date:8/26/2020)... ... August 24, 2020 , ... Elgia Therapeutics ... and fibrotic diseases, today announced that Dr. Stacie Canan has joined the company ... Canan previously served as Executive Director of Global Health at Bristol Myers Squibb ...
(Date:8/26/2020)... ... , ... Modality Solutions, a biopharmaceutical cold chain validation engineering firm, ... list is the most prestigious ranking of the nation’s fastest-growing private companies. Modality Solutions ... reported three-year revenue growth of 71 percent. , The Inc. 5000 list represents ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... , ... August 03, 2020 , ... Introducing Ardent Animal ... transformative growth, , Known as MediVet Biologics since its formation ... The new Ardent Animal Health will build on its base of innovative ...
(Date:7/31/2020)... Mass. and SOMERSET, N.J (PRWEB) , ... July ... ... leading genome editing company, and Catalent, the leading global provider of advanced delivery ... consumer health products, today announced that they have entered into a strategic partnership ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... , ... July 09, 2020 ... ... company, announced today that Massachusetts Institute of Technology (MIT) has expanded the ... license allows PathSensors to move into the point-of-care diagnostic market, focusing initially ...
Breaking Biology Technology:
Cached News: