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JCI table of contents, November 15 2004

Dr. Buckley cautions that while stem cell transplantation (involving transplanting bone marrow from a healthy sibling or other donor whose tissue type closely matches that of the patient's) is not a perfect therapy, there has been remarkable success in reestablishing the B and T cell population in SCID patients. However, gene therapy cannot be performed unless the abnormal gene for the specific patient is known. At Duke University alone, approximately 6% of recorded SCID cases have an unknown molecular basis. Identification of this new mutation in the CD3 epsilon chain will prompt doctors to examine such individuals for this mutation and hopefully allow suitable therapeutic steps, such as gene therapy, to be considered.

TITLE: Severe combined immunodeficiency caused by deficiency in either the delta or epsilon subunit of CD3.

AUTHOR CONTACT: Franoise Le Deist
INSERM and Hpital Necker-Enfants Malades, Paris, France.
Phone: 33-1-44-49-50-88; Fax: 33-1-42-73-06-40; E-mail: francoise.ledeist@nck.ap-hop-paris.fr.

View the PDF of this article at: https://www.the-jci.org/press/22588.pdf

ACCOMPANYING COMMENTARY:
TITLE: The multiple causes of human SCID

AUTHOR CONTACT: Rebecca H. Buckley
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
Phone: 919-684-2922; Fax: 919-681-7979; E-mail: buckL003@mc.duke.edu.

View the PDF of this commentary at: https://www.the-jci.org/press/23571.pdf

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Aging affects susceptibility to type 2 diabetes

Earlier research has reported a small but signif
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Nov-2004


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