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JCI table of contents, November 15 2004

nd colleagues developed an uncleavable form of pro-SF and used it in a gene therapy approach in mice to inhibit invasive tumor growth. Administration of the uncleavable pro-SF at the site of the tumor prevented the development of new blood vessels to the tumor, tumor growth, and tumor spread to other tissues, without affecting any normal physiological functions. The study demonstrates that the cleavage of pro-SF is an important step in the progression of tumor development and also suggests that drugs that inhibit this cleavage may lead to successful anti-cancer therapies.

TITLE: An uncleavable form of proscatter factor suppresses tumor growth and dissemination in mice.

AUTHOR CONTACT: Paolo Michieli
Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy.
Phone: 39-011-9933-219; Fax: 39-011-9933-225; E-mail: paolo.michieli@ircc.it.

View the PDF of this article at: https://www.the-jci.org/press/22235.pdf

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Researchers piece together the puzzle of Hailey-Hailey skin disease

Hailey-Hailey disease is a blistering skin disorder, usually inherited, and is characterized by a painful erosive skin rash that appears on the body in an unusual pattern of lines (Figure 1). The rash appears in a linear pattern on the extremities, S-shaped on the chest and abdomen, and V-shaped on the back. These lines are thought to trace the pathway of development of the ectoderm, one of the three layers of cells of the early human embryo and that which gives rise to skin and neural tissue.

It has been thought that individuals with Hailey-Hailey disease possess not one, but two or more genetically different populations of cells that o
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Nov-2004


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