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JCI table of contents, November 15 2004

nephrin, expressed by the podocytes and localized in the area of the SD, in the formation of this structure. Indeed, the fibers that constitute the SD appear to be formed largely by the association of extracellular nephrin strands. The authors examined a Finnish population of individuals lacking the nephrin protein due to a mutation in then nephrin gene, and also examined nephrin-deficient mice and found that in all cases the ordered SD structure was no longer evident and excessive protein levels were found in the urine.

In an accompanying commentary, William M. Deen from the Massachusetts Institute of Technology, discusses how the many parts of the glomerular capillary wall function to determine the permeability of this living ultrafiltration membrane.

TITLE: Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.

AUTHOR CONTACT: Karl Tryggvason
Department of Medical Biochemistry and Biophysics, Karolinksa Institute, Stockholm, Sweden.
Phone: 46-8-7287720; Fax: 46-8-316165; E-mail: karl.tryggvason@mbb.ki.se.

View the PDF of this article at: https://www.the-jci.org/press/22562.pdf

ACCOMPANYING COMMENTARY:
TITLE: What determines glomerular capillary permeability?

AUTHOR CONTACT: William M. Deen
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Phone: 617-253-4535; Fax: 617-253-2072; E-mail: wmdeen@mit.edu.

View the PDF of this commentary at: https://www.the-jci.org/press/23577.pdf

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Identifying the cellular sensor at work in polycystic ki
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Nov-2004


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