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rm of Rab27a a protein involved in vesicle trafficking and showed that mutant cells have a defect in docking of insulin-containing vesicles onto the cell membrane and diminished glucose-stimulated insulin release as a result. The results point to the Rab27a pathway as a new therapeutic target that may be manipulated in order to restore insulin secretion in diabetics.

In an accompanying commentary, Toru Aizawa and Mitsuhisa Komatsu from Shinshu University explain how glucose is metabolized by the b cell and discuss this new found role for Rab27a in facilitating insulin release in response to glucose.

TITLE: Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation

AUTHOR CONTACT:
Tetsuro Izumi
Gunma University, Gunma, Japan.
Phone: 81-27-220-8856; Fax: 81-27-220-8860; E-mail: tizumi@showa.gunma-u.ac.jp

This article is available at http://www.jci.org/cgi/content/full/115/2/388.

ACCOMPANYING COMMENTARY:

TITLE: Rab27a: a new face in b cell metabolism-secretion coupling

AUTHOR CONTACT:
Toru Aizawa
Shinshu University, Matsumoto, Japan.
Phone: 81-263-37-2157; Fax: 81-263-37-2183; E-mail: taizawa@gipac.shinshu-u.ac.jp

This article is available at http://www.jci.org/cgi/content/full/115/2/227.

SOCS2 socks it to growth hormone action

Treatment with growth hormone (GH) is used for a variety of disorders in children and adults. New findings published in the Journal of Clinical Investigation reveal a potential way to augment the anabolic and growth-promoting actions of GH. Christopher Greenhalgh and colleagues from The Walter and Eliza Institute of Medical Research disco
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Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Feb-2005


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