JCI table of contents: Au...( EDITOR'S PICK: New molecular regulato...)

JCI table of contents: Aug. 9, 2007

EDITOR'S PICK: New molecular regulators of hyperthyroidism and goiter

The thyroid gland has an important role in determining how much energy the body burns. Thyroid gland functions are regulated by a hormone known as thyroid-stimulating hormone (TSH). Increased levels of TSH, as well as increased signaling through the receptor for TSH, result in hyperthyroidism (characterized by weight loss because the body increases the amount of energy it burns) and goiter.

Signals downstream of the receptor for TSH had been thought to be mediated mainly by a protein complex known as Gs. But now, a study that appears online on August 9, in advance of publication in the September print issue of the Journal of Clinical Investigation, indicates that in mice Gq/G11-mediated signaling has an essential role in transmitting TSH-induced signals and therefore in regulating thyroid gland function. This makes Gq and G11 potential new targets for the treatment of hyperthyroidism and goiter.

In the study, Stefan Offermanns and colleagues from the University of Heidelberg, Germany, generated mice lacking the alpha-subunits of both Gq and G11 only in cells of the thyroid gland. These mice had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated downstream of these G proteins, might be of therapeutic benefit for individuals with diseases characterized by increased thyroid gland function and/or growth.

TITLE: Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development

AUTHOR CONTACT:
Stefan Offermanns
University of Heidelberg, Heidelberg, Germany.
Phone: 49-6221-54-8246; Fax: 49-6221-54-8549; E-mail:

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
9-Aug-2007

Page: 1 2 3 4 5
Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: August 1, 2007
3. US Department of Defense awards $1.6 million for implantable biochip research
4. More fish oil, less vegetable oil, better for your health
5. JCI table of contents -- July 26, 2007
6. JCI table of contents: July 19, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:

(Date:11/23/2009)...n, CT Current research suggests that a common ora...e related report by Nichols et al, "Unique Lipids ...s of TLR2 Ligands Capable of Enhancing Autoimmunit...rican Journal of Pathology . , Multiple sclerosi...the brain and spinal cord, affects nearly 1 in 700...

(Date:11/23/2009)..., Calif. - By producing some of the highest resolu...ces, scientists have a deeper understanding how bi...search may lead to a new treatment for kidney ston...ears in the Nov. 23 online edition of the journal ... explores how peptides interact with mineral surfa...

(Date:11/23/2009)... N.H. University of New Hampshire microbiologist ...15 to advance understanding of the actinorhizal pl...rich nutrient-poor and contaminated soils. , Th...warded Tisa, a professor of molecular, cellular an...biotic relationship between the bacteria Frankia a...

Breaking Biology News(10 mins):Factors from common human bacteria may trigger multiple sclerosis 2 Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 2 Scientists watch as peptides control crystal growth with 'switches, throttles and brakes' 3 UNH prof. receives nearly $500,000 to research environmentally significant plants 2 DIA 3rd Annual Clinical Trial Disclosure Workshop Offers Strategies for Creating Effective Registries and Results Databanks 54978 1 DIA 3rd Annual Clinical Trial Disclosure Workshop Offers Strategies for Creating Effective Registries and Results Databanks 54978 2 Film Event to Support United Cerebral Palsy 28UCP 29 of Central Arizona and the Phoenix Film Foundation 54975 1 Film Event to Support United Cerebral Palsy 28UCP 29 of Central Arizona and the Phoenix Film Foundation 54975 2 American Red Cross Provides Safety Tips for Rip Tides Caused by Hurricane Bill 54972 1 American Red Cross Provides Safety Tips for Rip Tides Caused by Hurricane Bill 54972 2

[0] Factors from common human bacteria may trigger multiple sclerosis [0] Scientists watch as peptides control crystal growth with 'switches, throttles and brakes'[0] UNH prof. receives nearly $500,000 to research environmentally significant plants

(Date:11/20/2009)..., Spain and Latin American countries have an oppo...y sectors. Researchers from the University of Vale...ation, have studied the productive fabric of the S... that Spain,s food and plant sectors have more clo...iotechnology as applied to food and plants has bee...

(Date:11/20/2009)..., , ROCKVILLE, Md., Nov. 20 /PRNewswire-... announced that it has priced an underwritten publ...k at a price to the public of $3.30 per share. Th... deducting the underwriting discounts and commissi...ical trials of our VLP-based vaccines, internal re...

(Date:11/20/2009)..., METTLER TOLEDO recently...actions Process Optimization Using At-Line Particl...cember 2, 2009. In this webinar, the application ...ed to map the design space and optimize a series o...ls, flow rates, and roller compaction forces. , ...

(Date:11/19/2009)..., , COPENHAGEN, Nov. 19 Dan... Inbicon cellulosic ethanol plant in Kalundborg, D... one of the world,s first and largest 2nd generati... Accellerase enzymes are used in the plant,s innov...or, a Division of Danisco, was the first to market...

Breaking Biology Technology:Spanish biotechnology should focus on food and plant sectors to be more competitive 2 Novavax Prices Public Offering of Common Stock 2 Roller Compaction Process Optimization Using At-Line Particle Characterization 2 DONG Energy and Inbicon Inaugurate One of the World's Largest Demo Plants for 2nd Generation Biofuel 2

[1] Spanish biotechnology should focus on food and plant sectors to be more competitive [0] Novavax Prices Public Offering of Common Stock [0] Roller Compaction Process Optimization Using At-Line Particle Characterization [0] DONG Energy and Inbicon Inaugurate One of the World's Largest Demo Plants for 2nd Generation Biofuel

Other News:

...earch suggests that physicians can distinguish bet...king, non-cancerous thyroid condition by simply de...ndings could lead to a test that will prevent the ...the noncancerous condition.......The study, led by...

Working mothers in the United States can relax. Their kids might still get into Harvard. A study from researchers at the University of Texas at Austin found no differences in children's social and int

...roup of scientists has accomplished the daunting t...ems on Earth, and the outlook is troubling.......C...lennium Ecosystem Assessment program will issue it...ces in London, Washington, D.C., Tokyo, Beijing,...

...rsity of Michigan scientists have identified a new...ice, kidney damage caused by chronic renal disease...lin/chordin-like protein, the new protein is the f... from bone morphogenetic proteins or BMPs, which a...

Cancerous or harmless? Three genes might tell the tale 2 Cancerous or harmless? Three genes might tell the tale 3 Quality of mom's time, not quantity, most important in early infant development 2 Scientists collaborate to assess health of global environment 2 Scientists collaborate to assess health of global environment 3 Protein protects kidneys from damage caused by chronic renal disease and injury 2 Protein protects kidneys from damage caused by chronic renal disease and injury 3 Protein protects kidneys from damage caused by chronic renal disease and injury 4

Cancerous or harmless? Three genes might tell the tale Quality of mom's time, not quantity, most important in early infant development Scientists collaborate to assess health of global environment Protein protects kidneys from damage caused by chronic renal disease and injury

Scientists in Britain tend to exclude controversial 'maverick' colleagues from their community to ensure they do not gain scientific legitimacy, new research has shown.......A Cardiff University study

... less effectively than scientists assumed, accordi...y researchers at UC Davis. This discovery will hel... is invading wetlands on the Pacific coast.......P...the wind to carry pollen between plants, fertilizi...

...t Cervical Cancer......Researchers from Maryland h...ins expressed in cervical cancer cells. Their fin...al of Virology.......Human papillomavirus (HPV) is... which is the second leading cause of cancer death...

Chromosomal Regions Containing Possible Prostate Cancer Susceptibility Genes Identified......A new study has identified five chromosomal regions that are likely to harbor prostate cancer susceptibilit

British scientists exclude 'maverick' colleagues, says report 2 Tips from the journals of the American Society for Microbiology 2 Tips from the journals of the American Society for Microbiology 3 Other highlights in the August 18 JNCI 2 Other highlights in the August 18 JNCI 3

British scientists exclude 'maverick' colleagues, says report Pollination find could lead to cordgrass control Tips from the journals of the American Society for Microbiology Other highlights in the August 18 JNCI