HOME >> BIOLOGY >> NEWS
JCI table of contents: December 15, 2005

he treatment of HSP patients but also for those individuals with other forms of peripheral nerve damage of known genetic origin.

TITLE: Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia

AUTHOR CONTACT:
Elena I. Rugarli
National Neurological Institute, Milan, Italy
Phone: 39-02-23942614; Fax: 39-02-23942619; E-mail: rugarli@istituto-besta.it

View the PDF of this article at: https://www.the-jci.org/article.php?id=26210

ONCOLOGY
Chromosomal quality control keeps leukemia in check

Researchers from Tokyo Medical and Dental University have discovered how failure of a quality control checkpoint in the cell cycle during replication and division allows incorrectly re-joined breaks in chromosomal DNA to go unrepaired, causing leukemia. Their results will be reported online on December 15 in advance of print publication in the January 2006 issue of the Journal of Clinical Investigation.

After DNA replication (known as G2 phase in the cell cycle), but before mitosis (M phase), the enzyme topoisomerase II (Topo II) drives the momentary breaking and rejoining of double-stranded DNA, a process that controls DNA over- and under-winding. With nearly 6 feet of DNA rotating at high speed and being twisted and folded into a microscopic space during cell replication, our cells require several systems or "checkpoints" for interrupting the cell cycle if something goes wrong. In normal cells, the checkpoint kinase ATM (ataxia telangiectasia mutated) can halt the cell cycle and prompt any necessary DNA repair.

While etoposide, a Topo II inhibitor, has been used for over 20 years in the treatment of a variety of malignancies, an unfortunate complication of this treatment is increased DNA strand breaks,
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
15-Dec-2005


Page: 1 2 3 4 5 6

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: JCI table contents December

(Date:9/1/2015)... , Sept. 1, 2015  Automation and ... during airport passenger screening. This is the first ... screening process will become unintrusive. An assortment of ... on voluntary background investigations will transform the passenger ... & Sullivan, Global Airport Passenger Screening Market ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Saudi Arabia Biomedical Sensors Market - Growth, Trends & ... The Saudi Arabia Biomedical Sensors market is estimated ... 3.64% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
(Date:8/26/2015)... , August 26, 2015 The ... and Five Factor), Application (Travel & Immigration, Government, Banking, ... Global Forecast to 2020", published by MarketsandMarkets, Multi-Factor Authentication ... 2020, growing at a CAGR of 17.7% between 2015 ... 82 F igures spread through 169 ...
Breaking Biology News(10 mins):The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 2The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 3The Future of Airport Security: Passenger Screening Transitioning Into an Invisible Process 4Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5
(Date:9/2/2015)... ZIONA, Israel , September 2, 2015 ... BVXV) today announced the intent of the National Institute of ... Institutes of Health (NIH) within the Department of Health and ... to be held in the United States ... use of BiondVax,s universal flu vaccine candidate, Multimeric-001 (M-001), as ...
(Date:9/2/2015)... ... 2015 , ... Advancing in medical imaging processing technology has ... in ICU to 3D skull printing analysis for Neurosurgery, ONYX ZEUS all-in-one surgical ... simultaneous access to high precision medical images and electronic health records. , ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... will improve efficiency of their entire waste to energy process and continue to ... Gets a Major Upgrade , Temarry’s Waste to Energy process has been operating ...
(Date:9/2/2015)... ... 2015 , ... Genedata, a leading provider of advanced software ... ® version 13.0 at ELRIG Drug Discovery 2015. This latest version of the ... new capabilities. Screener now supports High Throughput Flow Cytometry (HT-Flow) and Drug Metabolism ...
Breaking Biology Technology:BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 2BiondVax Announces Intent to Launch a Phase 2 Trial in the United States in Collaboration with the U.S. National Institutes of Health 3Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 2Surgical Workstation Powered by 6th Gen. Intel® Core™ Skylake Processors 3Temarry Recycling’s New $100,000 Waste to Energy Renovation 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 3New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 4
Cached News: