HOME >> BIOLOGY >> NEWS
JCI table of contents: July 12, 2007

EDITOR'S PICK

Src inhibitors may prove beneficial in breast cancer therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alphanegative cancers are more aggressive and have a worse prognosis than do ER-alphapositive breast cancers, and have been thought to be estrogen independent. In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Joyce Slingerland and colleagues from the University of Miami shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer.

In their study of 250 primary breast cancers, the authors found that ER mRNA levels overlap considerably between ER-alphapositive and ER-alphanegative breast cancers. This lack of correlation between ER-alpha mRNA and protein levels pointed to the existence of important post-transcriptional control of ER-alpha expression. They found that ER-alphanegative primary breast cancers and cell lines showed increased levels and/or activity of the protein Src, which cooperates with estrogen to activate ER-alpha breakdown via proteolysis. In line with this finding, Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis. The data raise the possibility that for at least a subset of ER-alphanegative breast cancers, Src may stimulate estrogen-dependent ER-alpha degradation, resulting in a lack of ER-alpha detection, and more aggressive tumor growth. The authors conclude that their study provides a rationale for the use of Src inhibitors in breast cancer therapy.

TITLE: Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer

AUTHOR CONTACT:
Joyce M. Slingerland
University of Miami Miller School of Medicine, Miami, Florida, USA.
Phone : (305) 243-7265;
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
12-Jul-2007


Page: 1 2 3 4 5

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners ... a Clinical Operations executive with expertise in clinical trial planning and feasibility, regulatory ... an Expert Consultant. Throughout his career, Mr. Movahhed has helped design and manage ...
(Date:8/5/2020)... ... August 05, 2020 , ... Regenative Labs has received approval ... CoreText™ and ProText™, making them the first Wharton’s jelly allografts to be assigned a ... The company’s solutions are the first Wharton’s jelly allograft product to be recognized as ...
(Date:7/18/2020)... SAN ANTONIO (PRWEB) , ... July 16, 2020 ... ... PLOS ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise ... (NICU) environment. The study reported that the Neoasis™ device attenuated the alarm sounds ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the ... the history of eSource, the reasons it did not take off as quickly as ... source, the industry is moving towards capturing data electronically for clinical trials and then ...
(Date:7/18/2020)... ... 2020 , ... “We are thrilled to deliver this new technology to the ... its kind on the market and we were pleased that the IFT jury recognized ... cultured ingredients, creating a natural way to extend the shelf life and improve the ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical transparency ... led by Dr MA has been using the zebrafish model to investigate the ...
(Date:7/1/2020)... ... June 29, 2020 , ... The Interlocal Purchasing System ... its membership, recently named BioFit Engineered Products an Awarded Vendor. Awarded ... ergonomic seating, cafeteria tables, book trucks and carts at discounted pricing without the ...
Breaking Biology Technology:
Cached News: