HOME >> BIOLOGY >> NEWS
JCI table of contents: July 19, 2007

EDITOR'S PICK

Mucins stand guard against gut infections

Mucins are large proteins that are secreted on the surface of the gut, and while long regarded as having a role as a barrier to mucosal infection, data to support this theory have been lacking. In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, Michael McGuckin and colleagues from the University of Queensland, Australia, show that cell surface mucin 1 (Muc1) plays a critical role in protecting the mucosal lining of the gut from bacterial infection.

These authors orally infected mice with the bacterial pathogen Campylobacter jejuni (a common cause of diarrhea) and found that 1 week after infection this organism could be detected in the organs of the vast majority of mice lacking Muc1, but never in mice with intact Muc1. Although this organism was able to enter the gastrointestinal epithelial cells lining the gut of both Muc1-deficient and Muc1-intact mice, intestinal damage was more common in Muc1-deficient animals, and the authors determined that the prevention of the spread of infection was exclusively due to Muc1 on the surface of gut epithelial cells. This is believed to be the first study in animals to demonstrate that cell surface mucins are a critical component of mucosal defense, and the role of these proteins in epithelial infections and inflammatory disease should be further examined.

TITLE: MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

AUTHOR CONTACT:
Michael A. McGuckin
University of Queensland, South Brisbane, Queensland, Australia.
Phone : 61-7-3840-2568; Fax: 61-7-3840-2550; E-mail: mmcguckin@mmri.mater.org.au

View the PDF of this article at: https://www.the-jci.org/article.php?id=26705


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
19-Jul-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... , ... July 01, 2020 , ... ... awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced today ... JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and overall ...
(Date:6/25/2020)... ... June 24, 2020 , ... ... and software-driven clinical data services that accelerate drug development, is collaborating with Karyopharm ... XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the first study ...
(Date:6/23/2020)... TORONTO (PRWEB) , ... June 22, 2020 , ... The ... time. Typically, ligand binding assays (LBA) have dominated this area. However, the use of ... several years. , This now necessitates the question “How do you choose which approach ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. ... can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI ... two switches in a push-pull configuration; yielding fast fall time for a capacitive ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... sciences industry, today announced the release of its signature product called Beacon ... Liaisons (MSLs) and other field medical professionals. , Beacon helps MSLs ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , ... sciences and food industries, is pleased to announce that Charles Galea has joined ... Development. , Charles is an accomplished and results-driven sales executive with over 10 ...
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in ... the patient's condition, treatment may be offered IV, intrathecal or with a combination. , ... dementia, and the incidence continues to increase as individuals live longer. There is no ...
Breaking Biology Technology:
Cached News: