JCI table of contents: July 19, 2007



In insulin resistance, all fingers point to diminished levels of PKC-lambda

Obesity, the metabolic syndrome, and type 2 diabetes are frequently characterized by insulin resistance a condition in which normal amounts of insulin are not adequate to produce a normal insulin response from fat, muscle, and liver cells. The result is an elevation in blood glucose levels. While the causes of insulin resistance are not completely defined, previous studies have suggested that an atypical protein kinase C (aPKC), PKC-lambda, regulates insulin-stimulated glucose transport. In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, a team led by Robert Farese at the University of South Florida generated mice lacking PKC-lambda specifically in muscle tissue and found that glucose transport and the activity of the glucose transporter GLUT4 were reduced in these animals and accompanied by body-wide insulin resistance, diabetes, abnormal insulin-producing beta cells, high cholesterol, and excess fat deposition in the abdomen and liver. The results show that insulin resistance and resultant effects, owing to a specific defect in muscle PKC-lambda, is sufficient to cause abdominal obesity and other abnormalities characteristic of the metabolic syndrome and type 2 diabetes.

TITLE: Muscle-specific knockout of PCK-lambda impairs glucose transport and induces metabolic and diabetic sydnromes

Robert V. Farese
University of South Florida College of Medicine, Tampa, Florida, USA.
Phone: (813) 972-7662; Fax: (813) 972-7623; E-mail: rfarese@health.usf.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=31408


Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:

(Date:8/7/2020)... ... August 06, 2020 , ... ... is pleased to announce that Eric Chen and Jessica Wong have joined the ... Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski ... with a near term focus on Type 2 diabetes and associated comorbidities. , ... multiple therapeutic areas and classes. As Chief Commercial Officer, Justin will lead ...
(Date:7/10/2020)... CHICAGO (PRWEB) , ... July 09, 2020 , ... Today ... Umami Advantage, which will share insight on the “fifth taste” phenomenon that is revolutionizing ... snacks. The Umami Advantage will be live on Monday, July 13, 2020 at11:00 AM ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... up to three different materials for use with CRM, neurostimulation, vascular, and related ... materials to meet specific design requirements, performance, and cost criteria; especially where solid ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... 16, 2020 , ... Medial EarlySign , a leader ... of high-burden diseases, and Centric Consulting, a business and technology consulting firm, today ... data in order to identify and prioritize patients for care. , Combining Centric’s ...
(Date:7/10/2020)... (PRWEB) , ... July 09, 2020 , ... ... called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish embryos, ... PolyU research team led by Dr MA has been using the zebrafish model ...
Breaking Biology Technology:
Cached News: