HOME >> BIOLOGY >> NEWS
JCI table of contents: July 19, 2007

IMMUNOLOGY

Keeping killer T cells under control in the liver

Natural killer (NK) T cells (of which type I and type II exist) are a small group of T cells in the blood that recognize and bind self- and foreign lipids. They rapidly release cytokines that can promote or suppress different immune responses, however the regulation of these responses is not well understood. In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, Vipin Kumar and colleagues from the Torrey Pines Institute for Molecular Studies examined the responses of these cells following their recognition of a self-glycolipid, sulfatide, and their relevance to inflammatory liver disease. They show that activation of sulfatide-reactive type II NKT cells caused recruitment of type I NKT cells into the liver in mice. These recruited type I NKT cells were anergic (ie. they were not able to mount a normal immune response against this self antigen) and as such were able to prevent experimentally-induced hepatitis in these animals. The authors went on to show that secretion of the cytokine IL-12 by dendritic cells in the liver and interaction of these dendritic cells with type II NKT cells was able to regulate the activity of type I NKT cells. The authors suggest that this activity could be exploited for the purpose of devising therapeutic interventions for inflammatory disease, including autoimmune diseases and asthma.

TITLE: Type II NKT cellmediated anergy induction in type I NKT cells prevents inflammatory liver disease

AUTHOR CONTACT:
Vipin Kumar
Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
Phone: (858) 455-3870; Fax: (858) 455-3804; E-mail: vkumar@tpims.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=316
'"/>


Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
19-Jul-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2019)... ... July 30, 2019 , ... Keck ... B. and Joy Rathmann Professor in Bioprocessing and Director of the Amgen Bioprocessing ... the life sciences industry and possesses more than 25 years of global experience ...
(Date:8/1/2019)... ... ... USDM Life Sciences (USDM) announces that Jay Crowley, Vice President of ... with the upcoming EU MDR IVDR regulations . , Jay is ... positions over his 26 years at the FDA, including developing the framework and authoring ...
(Date:7/24/2019)... ... 2019 , ... NDA Partners Chairman Carl Peck, MD ... than 20 years of experience working in scientific research and FDA-regulated environments including ... Expert Consultant. , Dr. Hartzfeld has experience in all aspects of quality, laboratory, ...
Breaking Biology News(10 mins):
(Date:8/6/2019)... ... August 06, 2019 , ... Shoreline Biome, ... to the strain level, has announced partnerships with six international distributors. , ... and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, Myanmar, New Zealand, Singapore, ...
(Date:7/30/2019)... (PRWEB) , ... July 30, 2019 , ... ... Diego’s premiere team building and cooking events company. Not only has the company ... has also started offering Private Cooking Parties to its guests. , With Lajollacooks4u’s ...
(Date:7/19/2019)... ... July 18, 2019 , ... World renowned ... be joining forces with California-based charity Coalition Duchenne for its 9th Annual Expedition ... raises awareness and funding for Duchenne muscular dystrophy and was founded by Sabahan ...
(Date:7/11/2019)... ... July 11, 2019 , ... At the most recent stem cell ... eight military Veterans under the R3 Heroes Program. The Veterans included individuals and families ... Program allow anyone to nominate a military Veteran, teacher or first responder to receive ...
Breaking Biology Technology:
Cached News: