HOME >> BIOLOGY >> NEWS
JCI table of contents: July 19, 2007

IMMUNOLOGY

Keeping killer T cells under control in the liver

Natural killer (NK) T cells (of which type I and type II exist) are a small group of T cells in the blood that recognize and bind self- and foreign lipids. They rapidly release cytokines that can promote or suppress different immune responses, however the regulation of these responses is not well understood. In a study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, Vipin Kumar and colleagues from the Torrey Pines Institute for Molecular Studies examined the responses of these cells following their recognition of a self-glycolipid, sulfatide, and their relevance to inflammatory liver disease. They show that activation of sulfatide-reactive type II NKT cells caused recruitment of type I NKT cells into the liver in mice. These recruited type I NKT cells were anergic (ie. they were not able to mount a normal immune response against this self antigen) and as such were able to prevent experimentally-induced hepatitis in these animals. The authors went on to show that secretion of the cytokine IL-12 by dendritic cells in the liver and interaction of these dendritic cells with type II NKT cells was able to regulate the activity of type I NKT cells. The authors suggest that this activity could be exploited for the purpose of devising therapeutic interventions for inflammatory disease, including autoimmune diseases and asthma.

TITLE: Type II NKT cellmediated anergy induction in type I NKT cells prevents inflammatory liver disease

AUTHOR CONTACT:
Vipin Kumar
Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
Phone: (858) 455-3870; Fax: (858) 455-3804; E-mail: vkumar@tpims.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=316
'"/>


Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
19-Jul-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... ... January 31, 2019 , ... Through its ... research support in study design, planning, sample collection, and analysis to researchers at ... Gynecology, and Dr. Sara Vaughn, MD, Reproductive Endocrinology and Infertility Fellow, to study ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, the leader in ... A2LA, which establishes requirements for medical laboratories to demonstrate competence to deliver timely, ... as well as College of American Pathologists (CAP)-accredited, a designation given to the ...
(Date:1/25/2019)... FRANCISCO (PRWEB) , ... January 24, 2019 , ... ... of Dr. Julia Oh, PhD, Assistant Professor of Microbiology at the Jackson Laboratory ... doctors from around the world, Dr. Oh will bring to uBiome expertise in ...
Breaking Biology News(10 mins):
(Date:1/21/2019)... ... 21, 2019 , ... Microbial Discovery Group (MDG), a leading ... institutional cleaning market. MDG’s SporActiv liquid and powder product line contains safe ingredients ... control, floor and tile cleaners, carpets, drains, portable restroom cleaning and more. ...
(Date:1/20/2019)... ... January 17, 2019 , ... Consumers ... the exclusive purview of physicians. That's changing as many services now exist for ... (DTC) laboratory testing market totaled $208 million in 2018, according to Kalorama Information’s ...
(Date:1/20/2019)... ... January 17, 2019 , ... ... Partner announces the launch of a specialized automation technology, titled Automate 3D. Automate ... automatic generation of models and drawings to deliver to end-users, customers, and ERP ...
(Date:1/15/2019)... (PRWEB) , ... January 15, 2019 , ... Personalized treatment ... for worsening kidney disease, according to a new study published in the journal Radiology. ... are frequently treated with partial nephrectomy, a surgical procedure in which the tumor and ...
Breaking Biology Technology:
Cached News: