HOME >> BIOLOGY >> NEWS
JCI table of contents: July 19, 2007

02


ONCOLOGY

A little more PDGF-BB, a little less tumor growth

The formation of new blood vessels (angiogenesis) is essential to provide nutrients to growing tumors. In the past, some researchers have hypothesized that the growth factor PDGF-BB (platelet-derived growth factor BB) contributes to tumor growth and spread by enhancing the envelopment of newly formed vessels with stabilizing pericytes, and rendering new vessels more resistant to anti-angiogenic therapies. In a surprising study appearing online on July 19 in advance of publication in the August print issue of the Journal of Clinical Investigation, a team led by Lee Ellis from The University of Texas MD Anderson Cancer Center found that when PDGF-BB was overexpressed in gastrointestinal cancer cells in the lab and then injected into mice, tumor growth was actually inhibited. In additional studies they treated PDGF-BBoverexpressing tumors with the drug imatinib mesylate (also known as Gleevec), which inhibits the PDGF-BB receptor, and this resulted in reduced pericyte content and increased tumor growth compared to tumors left untreated. They believe that these effects are due to an increased number of pericytes in the tumor, which can actually limit tumor angiogenesis, and in turn limit tumor growth. The authors conclude that the use of drugs that specifically target the PDGF receptor must therefore be used with caution for the treatment of tumors in which the PDGF receptor is not the target on the tumor cell itself.

TITLE: Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content

AUTHOR CONTACT:
Lee M. Ellis
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Phone: (713) 792-6926; Fax: (713) 792-4689; E-mail: lellis@mdanderson.org

View the PDF of this article at:

Contact: Brooke Grindlinger
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
19-Jul-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 12, 2007
8. JCI table of contents: June 21, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 2019 , ... VetStem Biopharma has long been ... experience. In November it spun out a human regenerative medicine subsidiary, ... of the first cGMP cell manufacturing facilities in California , VetStem signed ...
(Date:8/6/2019)... ... August 05, 2019 , ... ... announce its attendance at the Microscopy & Microanalysis 2019 Meeting ( M&M 2019 ... Oregon Convention Center. , The Microscopy & Microanalysis Meeting, organized by the Microscopy ...
(Date:8/4/2019)... ... August 02, 2019 , ... Stay on top of current hot topics ... industries. Access to all webinars is free, so be sure to register today to ... Visit http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , August ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An upcoming ... is scheduled to broadcast 4Q/2019. Check your local listings for more information. , ... generic drug delivery. Focusing on therapeutics for children and the elderly, viewers will ...
(Date:8/14/2019)... COLLEGE, Pa. (PRWEB) , ... August 13, 2019 ... ... in nuclear receptor and in vitro toxicology testing solutions, announced the appointment of ... healthcare industry experience to the Board. , Mark McLoughlin will lend his healthcare ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent ... for the IVA market . Inference will officially accept the award at Frost ...
(Date:8/6/2019)... DIEGO (PRWEB) , ... August 06, 2019 , ... ... Marketing Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast ... further growth. SDBN BUZZ podcast will also serve to promote the region and ...
Breaking Biology Technology:
Cached News: