HOME >> BIOLOGY >> NEWS
JCI table of contents: June 14, 2007

eber
Charite Universitatsmedizin Berlin, Berlin, Germany.
Phone : 49-30-450-528002; Fax:40-30-450-528902; E-mail: joerg.weber@charite.de

View the PDF of this article at: https://www.the-jci.org/article.php?id=30356


PHYSIOLOGY

You've got that painful feeling: How TRPA1 senses pain

Researchers have identified an interaction between the molecules transient receptor potential A1 (TRPA1) and proteinase-activated receptor 2 (PAR2) that may explain how we sense the pain caused by inflammation.

TRPA1 is present on a population of neurons and it forms channels that are important in sending signals in response to environmental irritants or other agents that cause inflammatory pain. PARs, also present on neurons, are known to play an important role in the response to tissue injury, notably in the process of inflammation and repair. Tryptase and trypsin, which are released from immune cells after injury, activate PAR2.

In their study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, Koichi Noguchi and colleagues from Hyogo College of Medicine, Japan, report that TRPA1 and PAR2 are significantly co-expressed in dorsal root ganglion neurons in rats and that PAR2 activation potentiates TRPA1 activity, resulting in the amplification of the pain sensation. They go on to show that this signaling pathway is dependent on the presence of the enzyme phospholipase C. The results represent a novel mechanism through which trypsin or tryptase released in response to tissue inflammation may trigger the sensation of pain through PAR2 activation. Therefore, compounds acting on TRPA1 or interfering with the interaction between TRPA1 and PAR2 may be useful in the treatment of inflammatory pain.

TITLE: Sensitization of TRPA1 by PA
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Jun-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 16, 2018 , ... ... R&D, today announced Genedata Imagence®, the industry’s first commercial and instrument-agnostic software ... solution accelerates, by orders of magnitude, the time-consuming and complex process of ...
(Date:10/16/2018)... , ... October 15, 2018 , ... ... chain operations solutions for highly regulated industries, is a silver sponsor and exhibitor ... Diego, California. , The Biomanufacturing World Summit brings together the “who’s ...
(Date:10/13/2018)... ... October 12, 2018 , ... uBiome, the leader in ... surgery, to its Medical Advisory Board. Joining the board of leading scientists and ... expertise in the surgical treatments of ulcerative colitis and Crohn's disease. The appointment ...
Breaking Biology News(10 mins):
(Date:10/5/2018)... CITY, Calif. (PRWEB) , ... October 04, 2018 ... ... infectious disease diagnostics with genomics, along with Duke University, announced today at IDWeek™ ... non-invasive blood test that detects pathogen DNA in plasma, accurately identified causative pathogens ...
(Date:10/2/2018)... ... October 02, 2018 , ... ... for biopharmaceutical R&D, today announced a new out-of-the-box integration of the ... leading international pharmaceutical and laboratory equipment supplier. This enables the automatic import ...
(Date:9/29/2018)... ... September 29, 2018 , ... Voxx Analytics announces the ... access the power of influence analytics and data-driven engagement decision making. , “For ... that didn’t necessarily have access to the same financial resources as our Top ...
(Date:9/27/2018)... N.J. (PRWEB) , ... September 26, 2018 , ... ... DNA testing are way ahead of their primary care physicians, according to a ... For this study, patients and doctors were asked about consumer adoption of fitness ...
Breaking Biology Technology:
Cached News: