JCI table of contents: June 14, 2007

R2 contributes to the sensation of inflammatory pain

Koichi Noguchi
Hyogo College of Medicine, Hyugo, Japan.
Phone : 81-798-45-6415; Fax: 81-798-45-6417; E-mail: noguchi@hyo-med.ac.jp

View the PDF of this article at: https://www.the-jci.org/article.php?id=30951


Progesterone and what to expect when you're expecting

The hormone progesterone is vital to ovulation and pregnancy, however various aspects of its roles throughout pregnancy are not well understood. A hurdle to expanding our knowledge of the effects of progesterone is the fact that progesterone-deficient mice cannot produce offspring. However, as FKBP52 is a molecule that acts to optimize signaling through the progesterone receptor, Fkbp52-/- mice provide a unique opportunity to study the roles of progesterone signaling throughout pregnancy.

In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, Sudhansu Dey and colleagues from Vanderbilt University first established that embryo implantation in the uterus in female Fkbp52-/- mice was not successful, mimicking the effect of the loss of progesterone, however daily progesterone supplementation enabled successful implantation of embryos in female Fkbp52-/- mice of one genetic background (referred to as C57BL6/129 Fkbp52-/- mice), but not another (CD1 Fkbp52-/- mice). The results indicate that FKBP52 deficiency-induced loss of uterine progesterone signaling is genetic background-specific. The authors went on to show that while progesterone supplementation at higher than normal pregnancy levels enabled progesterone receptor signaling sufficient for embryo implantation in the uterus in female CD1 Fkbp52-/- mice, these levels were not sufficient to maintain pregn

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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