JCI table of contents: June 14, 2007

ancy to full term. Progesterone levels had to be further elevated to achieve successful term pregnancy and a normal litter size.

In summary, the data reflect that the indispensability of FKBP52 in uterine progesterone signaling is genetic background- and pregnancy stage-specific. As there is evidence of a correlation between progesterone supplementation and a reduction in the risk of recurrent miscarriages and endometriosis in progesterone-deficient women, these findings have clinical implications for a genetically diverse population of women.

TITLE: FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific

Sudhansu K. Dey
Vanderbilt University, Nashville, Tennessee, USA.
Phone: (615) 322-8642; Fax: (615) 322-4704; Email: sk.dey@vanderbilt.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=31622


The heartbreaking loss of Gab1 and Gab2 in dilated cardiomyopathy

During dilated cardiomyopathy (DCM) the heart is weakened, enlarged, and no longer able to pump blood efficiently. In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, Naoki Mochizuki and colleagues from the National Cardiovascular Center Research Institute, Osaka, Japan, investigated the critical role of the proteins Gab1 and Gab2 in maintaining normal heart muscle function.

The authors examined mice lacking both Gab1 and Gab2, specifically in cardiomyocytes, and found that these animals exhibited dilated and malformed cardiac blood vessels and reduced cardiac contractility. They also found that Gab1 and Gab2 serve as essential mediators of signaling through the molecule neuroregulin-1beta (NRG-1beta). In their subse

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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