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JCI table of contents: June 14, 2007

nical Investigation, Liqing Yu and colleagues from Wake Forest University School of Medicine report that liver NPC1L1 allows the retention of cholesterol by liver cells and is also affected by Ezetimibe.

The authors found that mice created to overexpress human NPC1L1 in liver cells had a 30%-60% increase in plasma cholesterol levels. Administration to the mice of Ezetimibe normalized plasma cholesterol levels suggesting that Ezetimibe treatment in humans may reduce plasma cholesterol levels by inhibiting NPC1L1 in both intestine and liver and that liver NPC1L1 may have evolved to help protect the body from excessive changes in cholesterol levels.

TITLE: Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

AUTHOR CONTACT:
Liqing Yu
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phone : (336) 716-0920; Fax : (336) 716-6279; E-mail: lyu@wfubmc.edu

Mark Wright
Director, Office of Public Relations
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phone: (336) 716-3382; Email: mwright@wfubmc.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=30060


METABOLIC DISEASE

Uncoupling a high-fat diet from insulin resistance and diabetes

Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, Gerald Shulman and colleagues from Yale University Medical School report that overexpression of uncoupling protein 3 (UCP3) in the skeletal muscle of mice is able to protect against the development of high-f
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Jun-2007


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