HOME >> BIOLOGY >> NEWS
JCI table of contents: June 14, 2007

nical Investigation, Liqing Yu and colleagues from Wake Forest University School of Medicine report that liver NPC1L1 allows the retention of cholesterol by liver cells and is also affected by Ezetimibe.

The authors found that mice created to overexpress human NPC1L1 in liver cells had a 30%-60% increase in plasma cholesterol levels. Administration to the mice of Ezetimibe normalized plasma cholesterol levels suggesting that Ezetimibe treatment in humans may reduce plasma cholesterol levels by inhibiting NPC1L1 in both intestine and liver and that liver NPC1L1 may have evolved to help protect the body from excessive changes in cholesterol levels.

TITLE: Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe

AUTHOR CONTACT:
Liqing Yu
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phone : (336) 716-0920; Fax : (336) 716-6279; E-mail: lyu@wfubmc.edu

Mark Wright
Director, Office of Public Relations
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phone: (336) 716-3382; Email: mwright@wfubmc.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=30060


METABOLIC DISEASE

Uncoupling a high-fat diet from insulin resistance and diabetes

Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and is strongly associated with obesity. In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, Gerald Shulman and colleagues from Yale University Medical School report that overexpression of uncoupling protein 3 (UCP3) in the skeletal muscle of mice is able to protect against the development of high-f
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Jun-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Florida , April 11, 2017 ... a security technology company, announces the appointment of independent Directors ... Bendheim to its Board of Directors, furthering the company,s ... ... of NXT-ID, we look forward to their guidance and benefiting ...
(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... The research team of The Hong Kong ... identification by adopting ground breaking 3D fingerprint minutiae recovery and matching ... and accuracy for use in identification, crime investigation, immigration control, security ... ... A research team led by ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness ... targeting the needs of consumers who are incorporating medical marijuana into their wellness ... Arizona. , As operators of two successful Valley dispensaries, The Giving Tree’s two ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments ... consulting, Nanoscience Analytical offers a broad range of contract analysis services for ...
(Date:10/7/2017)... WALTHAM, Mass. , Oct. 6, 2017 /PRNewswire/ ... pioneering work of three scientists, Jacques Dubochet, ... whose breakthrough developments in cryo-electron microscopy ... this technology within the structural biology community. The ... Scientific. Scientists can now routinely produce highly resolved, ...
(Date:10/6/2017)... ... 2017 , ... On Tuesday, October 24th, ABC² (Accelerate Brain ... adaptive clinical trial for glioblastoma (GBM). The featured speaker will be Dr. Brian ... to the public, but registration is required. , WHAT: ABC² Brain Cancer ...
Breaking Biology Technology:
Cached News: