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JCI table of contents: June 14, 2007

at diet-induced insulin resistance.

Uncoupling proteins act to convert stored fat into thermal energy. In the current study the authors began by showing that mice fed a high-fat diet were markedly insulin resistant, a result of defects in insulin signaling in skeletal muscle and liver. In contrast, mice overexpressing UCP3 in skeletal muscle experienced increased whole body energy expenditure and were completely protected against fat-induced defects in insulin signaling and action in these tissues. They went on to delineate the events at the cellular levels that underlie this protective mechanism and suggest that some of these cellular events may serve as excellent therapeutic targets for the treatment of type 2 diabetes.

TITLE: Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

AUTHOR CONTACT:
Gerald I. Shulman
Yale University School of Medicine, New Haven, Connecticut, USA.
Phone : (203) 737-5447; Fax: (203) 737-4059; E-mail: gerald.shulman@yale.edu

View the PDF of this article at: https://www.the-jci.org/article.php?id=13579


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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Jun-2007


Page: 1 2 3 4 5 6 7

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