HOME >> BIOLOGY >> NEWS
JCI table of contents: June 21, 2007

Editor's Pick:A diet rich in omega-3 fatty acids may lower prostate cancer genetic risk

A diet rich in omega-3 polyunsaturated fatty acids found in certain fish or fish oil, nuts, seeds, and vegetable oils may help lower prostate cancer risk in individuals with a genetic predisposition to cancer. So conclude researchers from Wake Forest University School of Medicine in their study appearing online on June 21 in advance of publication in the July print issue of the Journal of Clinical Investigation.

While many genetic mutations are known to predispose to cancer, it has remained unclear whether dietary fat can modulate the risk of developing cancer in genetically predisposed individuals. Some studies suggest that a diet rich in omega-3 polyunsaturated fatty acids reduces cancer incidence. To determine the influence of fatty acids on prostate cancer risk in animals with a defined genetic predisposition to cancer, Yong Chen and colleagues studied Pten-knockout mice (which are predisposed to develop prostate tumors) and the effects on these mice of diets with defined levels of specific polyunsaturated fatty acids. The authors found that a nutritionally balanced diet high in omega-3 fatty acid reduced prostate tumor growth and increased survival in these animals, whereas omega-6 fatty acids had the opposite effects. Furthermore, introduction into the Pten-knockout mice of the enzyme omega-3 desaturase, which converts omega-6 to omega-3, reduced tumor growth in a manner similar to the omega-3 rich diet. The researchers went on to show that the effect of polyunsaturated fatty acids on prostate cancer development is mediated in part through cell death that is dependent on a protein known as Bad. Together, the data highlight the importance of the interaction between genes and diet in prostate cancer and imply a beneficial effect of omega-3 polyunsaturated fatty acids on delaying the onset of human prostate cancer. It will be interesting in future studies
'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
21-Jun-2007


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... ... February 06, 2020 , ... ... access to unique lab-made bioresearch materials, today announced an agreement with The ... meat and seafood a reality. Under the partnership, terrestrial meat and aquatic cell ...
(Date:2/5/2020)... SEATTLE (PRWEB) , ... February 05, 2020 , ... ... developed to bring greater ease, efficiency and insight to sample processing within ... of academic and biotech laboratories conducting research in various fields, LabKey Sample Manager ...
(Date:1/30/2020)... ... January 30, 2020 , ... Accelera Canada , a ... the Canadian market, is pleased to announce that the company has opened the doors ... company launched in 2017. , “We are so thrilled to now have all ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... , ... February 19, 2020 , ... ... solutions for the life sciences industry, today announced the opening of a new ... Associate Partner, Red Nucleus R&D. , Red Nucleus announced the new office in ...
(Date:2/10/2020)... , ... February 10, 2020 , ... R3 Medical Training ... March 13-14th, 2020 in Las Vegas. The course is hands on involving real ... For the past few years, the Comprehensive Stem Cell Training Course has received rave ...
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular ... that OmniType, the 11-locus, single tube multiplex successor to Holotype HLA is available ... featuring locus-multiplexing and short library preparation, for HLA genotyping from sample to answer ...
(Date:1/27/2020)... ... January 27, 2020 , ... ... and cloud and mobile computing, today announced the availability of neuroscience of transformational ... to use the latest neuroscience of leadership and change research to become great ...
Breaking Biology Technology:
Cached News: