JCI table of contents: June 21, 2007

to determine if any beneficial effects can also be achieved by supplementing the diet with omega-3 polyunsaturated fatty acids after tumor initiation has occurred.

Title: Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids

Author Contact:

Yong Q. Chen
Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Phone: (336) 713-7655; Fax (336) 713-7660; E-mail: yqchen@wfubmc.edu

Karen Richardson
Senior Media Relations Manager
Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.
Phone: (336) 716-4453; Fax: (336) 716-6841: Email: krchrdsn@wfubmc.edu

View the PDF of this article at: http://www.the-jci.org/article.php?id=31494


Mending a broken heart: How to boost the number and function of cardiac stem cells

A current hope is that cardiac stem cells could one day be manipulated to rebuild cardiac tissue damaged by heart disease. In a study appearing online on June 21 in advance of publication in the July print issue of the Journal of Clinical Investigation, Edward Morrisey and colleagues from the University of Pennsylvania address a fundamental question in the cardiac stem cell field what are the molecular pathways required for expansion and development of cardiac stem cells"

The authors have delineated a novel and essential pathway for the expansion of recently identified islet (Isl-1)positive cardiac progenitor cells. These cells help form the right ventricle and outflow tract of the developing heart. The authors show that Wnt signaling through activation of fibroblast growth factor 10 (FGF10) expression was required for expansion of Isl-1 cardiac progenitors in the anterior heart; loss of Wnt signaling lead to a l

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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