JCI table of contents: June 21, 2007

oss of the right ventricle and defective development of the outflow tract while sparing the left sided structures of the heart. Isl-1 positive precursor cells with active Wnt signaling were fated to become outflow tract and right ventricular muscle cells. Activation of Wnt signaling lead to increased numbers of Isl-1 positive progenitors, increased FGF10 expression, and increased outflow tract development. The direct relationship between Wnt and FGF10 signaling was demonstrated by the finding that FGF10 is a direct target of Wnt/beta-catenin signaling in cardiac development. These data identify a pathway by which the number and function of cardiac progenitor stem cells can be amplified, thus providing critical insight into the ability to harness these cells for future cardiac reparative therapies.

Title: Wnt/beta-catenin signaling promotes expansion of Isl-1 positive cardiac progenitor cells through regulation of FGF signaling

Author Contact:

Edward E. Morrisey
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 573-3010; Fax: (215) 573-2094; Email: emorrise@mail.med.upenn.edu

Marc Kaplan
Director of Communications
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Phone: (215) 662-2560; E-mail: Marc.Kaplan@uphs.upenn.edu

View the PDF of this article at: http://www.the-jci.org/article.php?id=31731


Autophagy plays a role in heart's poor response to stress

As a result of high blood pressure or cardiac injury the heart may compensate by increasing in size and mass a process known as hypertrophy. These changes may become irreversible after prolonged cardiac stress, resulting in diminished cardiac performance and possible heart failure. In a

Contact: Brooke Grindlinger
Journal of Clinical Investigation

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