JCI table of contents: June 21, 2007

study appearing online on June 21 in advance of publication in the July print issue of the Journal of Clinical Investigation, Joseph Hill and colleagues from the University of Texas Southwestern Medical Center examine the role of autophagy the tightly regulated recycling of cellular products leading to programmed cell death in heart failure. The authors found that pressure overload of the heart greatly increased cardiac autophagy and heart failure in mice. Furthermore, disruption of the gene encoding the protein Beclin1, a protein known to be required for autophagy, decreased cardiac muscle cell autophagy and diminished harmful structural changes to the heart under severe pressure stress. Conversely, Beclin 1 overexpression increased autophagy activity and the severity of harmful structural changes in the hearts of these animals. Taken together, the data implicate autophagy in the development of pressure/load-induced heart failure and as such it may be a target for novel therapeutic intervention.

Title: Cardiac autophagy is a maladaptive response to hemodynamic stress

Author Contact:

Joseph A. Hill
University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Phone : (214) 648-1400; Fax: (214) 648-1450; E-mail: joseph.hill@utsouthwestern.edu

View the PDF of this article at: http://www.the-jci.org/article.php?id=27523


All eyes are on the role of glutamate transporters in glaucoma

Glaucoma, a leading cause of irreversible blindness in the United States, usually occurs when increased fluid pressure in the eye damages the optic nerve. However, in a significant subset of glaucomas elevated intraocular pressure (IOP) is not a symptom [e.g. in normal tension glaucoma (NTG)] and in other cases a reduction in IOP does not prevent disease progression. In a

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:

(Date:8/23/2020)... ... August 21, 2020 , ... The August ... published and is now available on the company’s global website. Crystallography Times—an electronic ... community, presenting current news and crystallographic research. , The latest issue of ...
(Date:8/12/2020)... ... 2020 , ... Both Roche, based in Basel, Switzerland, and ... with Housey Pharma’s HMI subsidiary to gain access to its core-enabling technology for ... Development spending in excess of US $10 billion. , Scientists at Housey Pharma ...
(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping ... equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , ... for more than 10 years. Early in the COVID-19 crisis, we identified supply ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... Technology (MIT) has expanded the company’s exclusive license to include clinical applications ... point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast ...
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in Mexico ... patient's condition, treatment may be offered IV, intrathecal or with a combination. , A ... and the incidence continues to increase as individuals live longer. There is no cure, ...
(Date:7/1/2020)... GREEN, Ohio (PRWEB) , ... June 29, 2020 ... ... that offers access to competitively procured purchasing contracts to its membership, recently named ... to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, ...
(Date:6/28/2020)... , ... June 25, 2020 , ... ... racing to develop a vaccine or drug treatment. In an effort to better ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects from ...
Breaking Biology Technology:
Cached News: