JCI table of contents: June 21, 2007

el reveals that constant activation of AT1 leads to cardiac and renal fibrosis in spite of only a modest increase in blood pressure, and will be useful for investigating the role of angiotensin II in organs affected by some forms of human hypertension.

Title: Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice

Author Contact:

Eric Clauser
Institut Cochin, Paris, France
Phone : 33-153-73-27-50; Fax : 33-153-73-27-51; E-mail: clauser@cochin.inserm.fr

View the PDF of this article at: http://www.the-jci.org/article.php?id=28764


Dietary phytochemicals regulate detoxification enzyme CYP1A1

Cytochrome P450 1A1 (CYP1A1) is a detoxification enzyme that plays an important role in the metabolism of dietary toxins and orally absorbed drugs. It can also produce highly carcinogenic metabolites from polycyclic aromatic hydrocarbons. In a study appearing online on June 21 in advance of publication in the July print issue of the Journal of Clinical Investigation, Frank Gonzalez and colleagues from the National Cancer Institute report that dietary phytochemicals regulate whole-body CYP1A1 expression via an arylhydrocarbon nuclear translocator (Arnt) dependent system in the gut. The authors examined mice bred to lack Arnt expression in the intestinal epithelium and found that CYP1A1 expression and activity was markedly elevated in almost all non-gut tissues. Interestingly CYP1A1 expression was lost if the mice were fed a synthetic purified diet. However, CYP1A1 expression was restored following the addition of the natural phytochemical indole-3-carbinol to the diet of these mice. The data suggest that an Arnt-dependent pathway in the gut has an important role in the regulation of CYP1A1 expression and the metabolism of

Contact: Brooke Grindlinger
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 14, 2007
10. Food safety begins as vegetables grow
11. Turning the tables in chemistry

Post Your Comments:

(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for ... use of mass spectrometry in this field has gained a lot of momentum in ... which approach to use (LBA or MS)?” In many cases, either technology can ...
(Date:6/23/2020)... ... 2020 , ... In its June 22 online post, business and technology news ... M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb ... that starting July 5 it would begin offering free tissue stem cell counting ...
(Date:6/19/2020)... SAN DIEGO (PRWEB) , ... ... ... host a three-part webinar series, “Automate Your Lab with Software for Data ... engineers. Attendees will learn how to integrate and automate cutting-edge scientific instruments ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... chain validation engineering firm, is making available for free its new white ... incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). In ...
(Date:8/7/2020)... Texas (PRWEB) , ... August 06, 2020 , ... ... and DNA vaccine industries, announces it has closed on the purchase of greenfield ... Park in Conroe, TX and includes over 21 acres in the initial acquisition, ...
(Date:8/3/2020)... ... , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions ... as MediVet Biologics since its formation in 2016, the company is relaunching itself under ... build on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
Breaking Biology Technology:
Cached News: