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JCI table of contents: June 21, 2007

el reveals that constant activation of AT1 leads to cardiac and renal fibrosis in spite of only a modest increase in blood pressure, and will be useful for investigating the role of angiotensin II in organs affected by some forms of human hypertension.

Title: Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice

Author Contact:

Eric Clauser
Institut Cochin, Paris, France
Phone : 33-153-73-27-50; Fax : 33-153-73-27-51; E-mail: clauser@cochin.inserm.fr

View the PDF of this article at: http://www.the-jci.org/article.php?id=28764


Physiology

Dietary phytochemicals regulate detoxification enzyme CYP1A1

Cytochrome P450 1A1 (CYP1A1) is a detoxification enzyme that plays an important role in the metabolism of dietary toxins and orally absorbed drugs. It can also produce highly carcinogenic metabolites from polycyclic aromatic hydrocarbons. In a study appearing online on June 21 in advance of publication in the July print issue of the Journal of Clinical Investigation, Frank Gonzalez and colleagues from the National Cancer Institute report that dietary phytochemicals regulate whole-body CYP1A1 expression via an arylhydrocarbon nuclear translocator (Arnt) dependent system in the gut. The authors examined mice bred to lack Arnt expression in the intestinal epithelium and found that CYP1A1 expression and activity was markedly elevated in almost all non-gut tissues. Interestingly CYP1A1 expression was lost if the mice were fed a synthetic purified diet. However, CYP1A1 expression was restored following the addition of the natural phytochemical indole-3-carbinol to the diet of these mice. The data suggest that an Arnt-dependent pathway in the gut has an important role in the regulation of CYP1A1 expression and the metabolism of
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Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
21-Jun-2007


Page: 1 2 3 4 5 6 7

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