JCI table of contents: March 15, 2007

EDITOR'S PICK: Gallium: a new antibacterial agent?

New antibacterial strategies are needed because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradicating chronic bacterial infections. One approach to developing new antibacterial strategies, taken by researchers from the University of Washington, Seattle, is to limit the amount of iron (Fe), which is critical for bacterial growth, to which bacteria have access.

In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pradeep Singh and colleagues show that Gallium (Ga), which is chemically similar to Fe and can disrupt biological systems by substituting for Fe, inhibits the in vitro growth of Pseudomonas aeruginonsa; even multidrug resistant strains of P. aeruginonsa isolated from individuals with cystic fibrosis. Ga also prevented P. aeruginonsa forming biofilms, the multi-cellular bacterial communities responsible for chronic bacterial infections, and killed both free-living bacteria and bacteria in biofilms. Furthermore, inhalation of Ga protected mice from both acute and chronic P. aeruginonsa lung infections. As Ga is already FDA approved for the treatment of hypercalcemia of malignancy, these data suggest that Ga might be a promising new therapeutic for the treatment of infection with P. aeruginonsa, a major cause of infection in individuals with cystic fibrosis and of infection acquired in hospital.

TITLE: The transition metal gallium disrupts Pseudomonas aeruginonsa iron metabolism and has antimicrobial and antibiofilm activity

Pradeep K. Singh
University of Washington School of Medicine, Seattle, Washington, USA.
Phone: (206) 221-7151; Fax: (206) 543-8297; E-mail: singhpr@u.washington.edu.

View the PDF of this article at:

Contact: Karen Honey
Journal of Clinical Investigation

Page: 1 2 3 4 5

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
TAG: JCI table contents March

(Date:10/5/2015)... -- http://soundview.co ) releases the ... NXTD ), a biometric authentication company focused on ... ) releases the following market and company ... biometric authentication company focused on the growing mobile commerce ... ) releases the following market and company ...
(Date:9/30/2015)... , Sept. 30, 2015  The global glucose monitoring device ... 2015. So says a new report on the industry from ... segment dominate the market, followed by continuous glucose monitoring and ... on the market for these products in its latest report, ... , ...
(Date:9/28/2015)... 28, 2015 The global ... USD 12.03 billion by 2020, growing at a CAGR ... as Backside Illumination (BSI) technique to improve picture quality ... period.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757) , ... to reduce loss and, thus, reduce the noise interference ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... BALTIMORE, Maryland , October 8, 2015 /PRNewswire/ ... http://www.GoldmanResearch.com .   --> Goldman ... specializing in the small cap and microcap sectors, ... sponsored research report on PharmaCyte Biotech, Inc. (OTCQB ... company focused on developing and preparing treatments for ...
(Date:10/8/2015)... 8, 2015  The ALS Association, in partnership with ... Challenge to revolutionize communication technology solutions for people living ... ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative ... and the spinal cord. Eventually, people with ALS lose ... often leads to total paralysis and death within two ...
(Date:10/8/2015)... ... , ... Talon Innovations, a provider of Precision Machined Products and ... is one of three finalists for the Minnesota Business magazine’s Manufacturing Award in the ... Innovations was recognized as a nominee for this competitive award. , The “Best ...
(Date:10/7/2015)... 7, 2015 Boston Scientific (NYSE: ... the Boston Scientific Connected Patient Challenge , an ... use of remote patient monitoring to enhance patient care.  ... can submit their ideas and collaborate on solutions through ... Cambridge, MA where they ...
Breaking Biology Technology:
Cached News: