JCI table of contents: Octobe...( rsity generated mice expressing only on...)

rsity generated mice expressing only one copy of Nf1 (Nf1+/- mice). Nf1+/- mice were found to have increased numbers of osteoclasts, which are cells that degrade and resorb bone. These osteoclasts were better at surviving, proliferating, and degrading bone than osteoclasts from normal mice. These abnormal characteristics were associated with increased activity of two signaling molecules, p21ras and PI3K. Importantly, in this study, which appears online on October 19 in advance of publication in the November print issue of the Journal of Clinical Investigation, it was shown that osteoclasts from individuals with NF1 have the same characteristics as osteoclasts from Nf1+/- mice. This study not only provides insight into why individuals with NF1 suffer from osteoporosis, but also leads the authors to suggest that targeting PI3K might be a viable therapy for treating all individuals with osteoporosis.

TITLE: Hyperactivity of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1haploinsufficient osteoclast functions

AUTHOR CONTACT:

D. Wade Clapp
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phone: (317) 278-9290; Fax: (317) 274-8679; E-mail: dclapp@iupui.edu.

Feng-Chun Yang
Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phone: (317) 278-9290; Fax: (317) 274-8679; E-mail: fyang@iupui.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=29092

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Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
19-Oct-2006


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