HOME >> BIOLOGY >> NEWS
JCI table of contents: September 1, 2006

EDITOR'S PICK: Estrens might not be the answer for osteoporosis

A new study appearing in the September issue of the Journal of Clinical Investigation indicates that caution might be needed if a new group of drugs known as estrens are to be developed for the treatment of osteoporosis. The researchers found that although estrens improved bone strength in mice with osteoporosis, they also had adverse effects on reproductive organs and human breast cancer cells.

Many individuals, in particular women who have gone through the menopause, suffer from osteoporosis -- a disease in which the bones become fragile and highly susceptible to fracture. Bone strength is naturally maintained by a group of hormones known as sex hormones (for example, estrogen). However, unnaturally high levels of these hormones cause cancer of the reproductive organs and breast tissue, meaning that they cannot be used to treat individuals with osteoporosis. So, researchers have long been searching for estrogen-like molecules that increase bone strength but do not cause cancer. Recently, a new set of molecules (known as estrens) said to have these properties were identified. However, the wisdom behind developing estrens for use in the clinic is questioned by Roland Baron and colleagues from Yale University. They showed that although mice with osteoporosis treated with estrens showed some improvement in bone strength, their reproductive organs increased in size. Furthermore, estrens induced the proliferation of human breast cancer cells. This study indicates that estrens might not be the sought after estrogen-like molecules that improve bone strength but do not cause cancer, and has important implications for their clinical development.

In an accompanying commentary, Ushma S. Neill from The Journal of Clinical Investigation discusses the evidence for and against the use of estrens to treat osteoporosis, and concludes that we will have to wait for the completion o
'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Sep-2006


Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2020)... Kingdom (PRWEB) , ... May 22, 2020 , ... Oxford ... for the detection of SARS-CoV-2, the virus that causes COVID-19. , The ... on-demand analysis of smaller sample numbers, to very large numbers of samples. Hardware ...
(Date:5/21/2020)... ... May 20, 2020 , ... Catalent, ... drugs, biologics, cell and gene therapies, and consumer health products, today announced that ... be presenting at the ISCT 2020 Paris Virtual conference, which takes place on ...
(Date:5/15/2020)... ... May 15, 2020 , ... The National Institutes of Health (NIH) ... based in Frederick, Maryland and Tysons Corner, Virginia, to provide patent legal services under ... another in the field of chemistry. The firm is one of nine firms in ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... May 14, 2020 , ... This new service offers clients ... most pressing questions answered quickly as the need arises. Lachman’s OnCall SMEs have extensive ... at affordable rates. , Lachman OnCall™ SMEs are available normal business hours Monday ...
(Date:5/14/2020)... WILMINGTON, Del. (PRWEB) , ... May 12, 2020 ... ... selection of Interdisp JCS as the new distribution partner for all personal care ... the DuPont GENENCARE®OSMS portfolio and DuPont preservative portfolio for personal care. , ...
(Date:5/14/2020)... ... May 13, 2020 , ... In ... Lab: Optimizing Workflows in the Life Science Lab . The comprehensive information source ... from water purification and liquid handling to contamination control. , The content hub ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
Breaking Biology Technology:
Cached News: