HOME >> BIOLOGY >> NEWS
JCI table of contents: September 21, 2006

/A>.

View the PDF of this article at: https://www.the-jci.org/article.php?id=27209


PARASITOLOGY: Brucipain gives parasite open access to the brain

It is estimated that 40,000 people in sub-Saharan Africa die every year of sleeping sickness. Sleeping sickness occurs when individuals become infected with one of two parasites, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense. The final stages of the disease are characterized by neurological defects and occur when the parasite leaves the bloodstream and enters the brain. The mechanisms by which the parasites invade the brain have not been well defined. Now, in a study using human cells in culture, which appears online on September 21 in advance of publication in the October print issue of the Journal of Clinical Investigation, researchers from Johns Hopkins School of Medicine, have shown that the T. b. gambiense protein brucipain, which can destroy other proteins, enables the parasite to get past the cells that act as a barrier between the blood and the brain.

Dennis Grab and colleagues showed that inhibitors of brucipain prevented T. b. gambiense getting past the cells that act as a barrier to entry into the brain. Conversely, a mixture of the soluble factors produced by T. b. gambiense, which includes brucipain, helped a related parasite T. b. brucei that normally cannot get past these barrier cells cross the barrier. Further analysis showed that brucipain activates the cells that form the barrier to the brain, but exactly how this provides T. b. gambiense access to the brain remains to be determined.

TITLE: Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

AUTHOR CONTACT: Dennis J. Grab Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Phone: (410) 614-3917; Fax: (410) 614-1
'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
21-Sep-2006


Page: 1 2 3 4 5 6 7

Related biology news :

1. Antioxidant overload may underlie a heritable human disease
2. JCI table of contents: Aug. 9, 2007
3. JCI table of contents: August 1, 2007
4. US Department of Defense awards $1.6 million for implantable biochip research
5. More fish oil, less vegetable oil, better for your health
6. JCI table of contents -- July 26, 2007
7. JCI table of contents: July 19, 2007
8. JCI table of contents: July 12, 2007
9. JCI table of contents: June 21, 2007
10. JCI table of contents: June 14, 2007
11. Food safety begins as vegetables grow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/29/2020)... THE WOODLANDS, Texas (PRWEB) , ... January 29, ... ... clinical grade DNA plasmid, announced it will start production of a DNA vaccine ... an agreement executed with Inovio Pharmaceuticals. A grant of up to $9 million ...
(Date:1/28/2020)... ... 28, 2020 , ... Blue Health Intelligence (BHI) published an ... care, and limit the utilization of high-cost imaging and surgeries for musculoskeletal (MSK) ... Texas specializes in improving care delivery for MSK conditions. In an independent study ...
(Date:1/27/2020)... , ... January 27, 2020 , ... ... Chairman. Thorne is a noted investor, tech entrepreneur, and former senior management consultant ... Chairman of Broadline Capital, the global alternative investment firm. , “Chris Thorne ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... ... February 20, 2020 , ... ... and elegant chemistry. Humans have been increasingly successful in innovating ways to ... rapidly evolving technologies and strategies for modern molecular biology (e.g., gene sequencing, ...
(Date:2/21/2020)... ... February 21, 2020 , ... Pharmaceutical manufacturers ... in order to adapt to new approaches like ‘Industry 4.0’ and continuous manufacturing, ... for personalized medicine and therapies. But with an industry with the world’s tightest ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... the life sciences industry, today announced the opening of a new office in ... Red Nucleus R&D. , Red Nucleus announced the new office in response to ...
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro Technologies, ... America, today announced that the City of Fort Worth has partnered with Synagro ... Commencing in April of 2020, Synagro will assume operation of the city’s current ...
Breaking Biology Technology:
Cached News: